P
Pierre Renard
Researcher at University of Caen Lower Normandy
Publications - 154
Citations - 4362
Pierre Renard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 34, co-authored 154 publications receiving 4150 citations. Previous affiliations of Pierre Renard include Blaise Pascal University & Paul Sabatier University.
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Journal ArticleDOI
Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.
Pascale Moreau,Nathalie Gaillard,Christelle Marminon,Fabrice Anizon,Nathalie Dias,Brigitte Baldeyrou,Christian Bailly,Alain Pierré,John A. Hickman,Bruno Pfeiffer,Pierre Renard,Michelle Prudhomme +11 more
TL;DR: The 3,9-dihydroxy derivative is the most efficient compound of this series of glycosylated indolocarbazoles and characterized as a DNA binding topoisomerase I poison, which likely accounts for its cytotoxic potential.
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Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.
Christophe Mesangeau,Basile Pérès,Descamps-Francois Carole,Philippe Chavatte,Valérie Audinot,Sophie Coumailleau,Jean A. Boutin,Philippe Delagrange,Caroline Bennejean,Pierre Renard,Daniel H. Caignard,Pascal Berthelot,Saïd Yous +12 more
TL;DR: It is confirmed that the selectivity seen for the MT(1) receptor arises predominantly from steric factors and is not a consequence of the bridging of melatonin receptor dimers.
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Synthesis of granulatimide analogues bearing a maleimide instead of an imidazole heterocycle
TL;DR: In this article, a new family of granulatimide analogues was synthesized in a few steps by replacing the imidazole unit with a maleimide moiety.
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N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
Nicolas Inguimbert,Hervé Poras,Franck Teffo,Françoise Beslot,Mohamed Selkti,Alain Tomas,Elizabeth Scalbert,Caroline Bennejean,Pierre Renard,Marie-Claude Fournie-Zaluski,Bernard-Pierre Roques +10 more
TL;DR: The synthesis and biological activities of analogues derived from this lead with inhibitory potencies in the nanomolar range for the three enzymes are reported, including compounds 8b and 15c which are the most potent triple inhibitors described to date.
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Synthesis of new aromatic pyrrolo[2,1-c] [1,4]benzodiazepines and pyrrolo[1,2-a]thieno[3,2-e] [1,4]diazepines as anti-tumoral agents.
Vincent Lisowski,Frédéric Fabis,Alain Pierré,Daniel-Henri Caignard,Pierre Renard,Sylvain Rault +5 more
TL;DR: Diazepine analogs of thieno[2,3- b] pyrrolizin-8-ones were synthesized by aromatization of 2-hydroxypyrrolo[1,2- a] thiena diazepines, with the best result being for the mixture of the isomers 5 and 6 which showed a 0.35 μM IC 50 against cell growth.