P
Pierre Renard
Researcher at University of Caen Lower Normandy
Publications - 154
Citations - 4362
Pierre Renard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 34, co-authored 154 publications receiving 4150 citations. Previous affiliations of Pierre Renard include Blaise Pascal University & Paul Sabatier University.
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Journal ArticleDOI
Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases.
Aurélien Vidal,Massimo Sabatini,Gaëlle Rolland-Valognes,Pierre Renard,Jean-Claude Madelmont,Emmanuelle Mounetou +5 more
TL;DR: Quaternary ammonium conjugates of tetracyclines synthesized by direct alkylation of the amine function at the 4-position with methyl iodide inhibited cytokine-induced MMP expression to a lesser extent and could be potent drug candidates for cartilage- targeting chondroprotective treatment.
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Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligands
Sophie Poissonnier-Durieux,Mohamed Ettaoussi,Basile Peres,Jean A. Boutin,Valérie Audinot,Caroline Bennejean,Philippe Delagrange,Daniel Henri Caignard,Pierre Renard,Pascal Berthelot,Daniel Lesieur,Saïd Yous +11 more
TL;DR: N-[2-(3-hydroxymethylphenyl)-7-methoxynaphth-1-yl)ethyl]acetamide (21) is one of the best MT(2) selective ligands described until now and behaves as an antagonist.
Journal ArticleDOI
Regulation of emotional behaviour by day length in mice: implication of melatonin.
C Kopp,Elise Vogel,Marie-Claire Rettori,P Delagrange,Pierre Renard,Daniel Lesieur,René Misslin +6 more
TL;DR: Evidence is provided that the modulation of circulating melatonin could be involved in the emotional changes related to day-length variations, and whether pinealectomy could counteract the photoperiod-related changes in anxiety.
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Synthesis and pharmacology of pyrid-3-yl sulfonylureas and thioureas as astrocytic Na+ 2Cl- K+ cotransporter inhibitors
TL;DR: The pharmacology of lipophilic 4-arylamino- and 4-cycloalkylaminopyrid-3-ylsulfonyl(thio)ureas and their synthesis designed from torasemide could lead to a method of inhibiting the astrocytic Na+ 2C1− K+ cotransporter and thus treating cerebral edema.
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Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3
Mohamed Ettaoussi,Basile Péres,Frederique Klupsch,Philippe Delagrange,Jean-A. Boutin,Pierre Renard,Daniel-H. Caignard,Philippe Chavatte,Pascal Berthelot,Daniel Lesieur,Saïd Yous +10 more
TL;DR: Benzofuranic analogues of MCA-NAT (5-methoxycarbonylamino-N-acetyltryptamine) have been synthesized and evaluated as melatonin receptor ligands and introduction of a methoxycarbonic substituent in the C-5 position of the benzofurane nucleus obtains MT(3) selective ligands.