P
Pierre Renard
Researcher at University of Caen Lower Normandy
Publications - 154
Citations - 4362
Pierre Renard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 34, co-authored 154 publications receiving 4150 citations. Previous affiliations of Pierre Renard include Blaise Pascal University & Paul Sabatier University.
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Efficient selective synthesis of 2-substituted indoles from complex-base-promoted arynic cyclisations
TL;DR: 2-Substituted indoles have been efficiently obtained by selective arynic cyclisation of halogenated aryl imines of methyl ketones in the presence of the complex-base NaNH2–ButONa and by PhCH2SH–AlCl3 opening of tetrahydrothiopyranoindoles.
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Synthesis of tetracyclic dioxygenated isoquinolines and their cytotoxic activity
TL;DR: In this paper, an efficient synthesis of new dioxygenated isoquinolines was reported using tricyclic-nitril as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoquinoline and its derivatives.
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Novel Selective and Partial Agonists of 5‐HT3 Receptors. Part 1. Synthesis and Biological Evaluation of Piperazinopyrrolothienopyrazines.
Sylvain Rault,Jean-Charles Lancelot,Herve Prunier,Max Robba,Pierre Renard,Philippe Delagrange,Bruno Pfeiffer,Daniel-Henri Caignard,Béatrice Guardiola-Lemaitre,Michel Hamon +9 more
TL;DR: A series of piperazinopyrrolo[1,2-a]thieno[3, 2-e]- and -[2,3-e]pyrazine derivatives were prepared and evaluated in order to determine the necessary requirements for high affinity on the 5-HT3 receptors and high selectivity versus other 5HT receptor subtypes.
Journal Article
Synthesis of 6-dialkylaminoalkylamino pyrano[2,3-c]acridones and benzo[b]pyrano[3,2-h]acridones: soluble acronycine analogues with increased cytotoxic activity.
Nadine Costes,Abdelhakim Elomri,T. Hanh Dufat,Sylvie Michel,Elisabeth Seguin,Michel H. J. Koch,François Tillequin,Bruno Pfeiffer,Pierre Renard,Stéphane Léonce,Alain Pierre +10 more
TL;DR: In both series, the introduction of a dialkylaminoalkylamino side chain at position 6 resulted in a significant increase of the cytotoxic activity against L1210 cells when compared with the parent compounds bearing a methoxy group, accompanied with an increased potency to arrest cells in the G2 + M phases of the cell cycle.
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Analogues of antifungal tjipanazoles from rebeccamycin.
Aline Voldoire,Pascale Moreau,Martine Sancelme,Mária Matulová,Stéphane Léonce,Alain Pierré,John A. Hickman,Bruno Pfeiffer,Pierre Renard,Nathalie Dias,Christian Bailly,Michelle Prudhomme +11 more
TL;DR: The most cytotoxic compound in the series was a dinitro derivative characterized as a potent topoisomerase I inhibitor.