P
Pierre Vassalli
Researcher at University of Geneva
Publications - 149
Citations - 19681
Pierre Vassalli is an academic researcher from University of Geneva. The author has contributed to research in topics: Tumor necrosis factor alpha & Antigen. The author has an hindex of 69, co-authored 149 publications receiving 19383 citations. Previous affiliations of Pierre Vassalli include University of Lausanne & Pasteur Institute.
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The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
TL;DR: It is proposed that TNF released from macrophages in the microenvironment of developing granulomas is involved in a process of autoamplification: acting in an autocrine or paracrine way, it enhances its own synthesis and release, thus favoring further macrophage accumulation and differentiation leading to bacterial elimination.
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Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.
TL;DR: This study characterizes the interaction of murine macrophage nuclear proteins with the tumor necrosis factor alpha (TNF-alpha) promoter and proposes that this induced form of NF-kappa B contains both the 50- and 65-kDa protein subunits, the latter ones being necessary to bind NF- kappa B to its cytoplasmic inhibitor in uninduced cells.
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Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
Georges E. Grau,Terrie E. Taylor,Malcolm E. Molyneux,Jack J. Wirima,Pierre Vassalli,Marcel Hommel,Paul-Henri Lambert +6 more
TL;DR: The level of tumor necrosis factor is frequently increased in patients with severe falciparum malaria, particularly in those with cerebral malaria or hypoglycemia, and whether it is important in the pathogenesis of the signs and symptoms of the disease requires further study.
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Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.
TL;DR: It is speculated that NF-kappa B and/or related proteins are involved in the LPS-induced transcriptional activation of the TNF-alpha gene, and that factors interacting with the Y box can additionally modulate the activity of the gene in macrophages.
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In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices.
TL;DR: Results showed that capillary endothelial cells have the capacity to form vessel-like structures with well-oriented cell polarity in vitro and suggest that an appropriate topological relationship of endothelium cells with collagen matrices has an inducive role on the expression of this potential.