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Arturo V. Orjalo
Researcher at Buck Institute for Research on Aging
Publications - 29
Citations - 4868
Arturo V. Orjalo is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: RNA & Gene expression. The author has an hindex of 19, co-authored 29 publications receiving 4140 citations. Previous affiliations of Arturo V. Orjalo include Baylor College of Medicine & Genentech.
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Journal ArticleDOI
Inflammatory Networks during Cellular Senescence: Causes and Consequences
Adam Freund,Arturo V. Orjalo,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +5 more
TL;DR: The secreted factors that make up the proinflammatory phenotype of senescent cells are listed and the impact of these factors on tissue homeostasis is described and the cellular pathways/processes known to regulate this phenotype are summarized.
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge,Yu Sun,Arturo V. Orjalo,Christopher K. Patil,Adam Freund,Lili Zhou,Samuel C. Curran,Albert R. Davalos,Kathleen A. Wilson-Edell,Su Liu,Chandani Limbad,Marco Demaria,Patrick Wai-Lun Li,Gene B. Hubbard,Yuji Ikeno,Martin A. Javors,Pierre Yves Desprez,Christopher C. Benz,Pankaj Kapahi,Peter S. Nelson,Judith Campisi +20 more
TL;DR: It is shown that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells, which might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
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Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
TL;DR: It is shown that cell surface-bound IL-1α is essential for signaling the senescence-associated secretion of IL-6 and IL-8, 2 proinflammatory cytokines that also reinforce the senescent growth arrest and regulates the biological effects of these cytokines.
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MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.
Dipa Bhaumik,Gary K. Scott,Shiruyeh Schokrpur,Christopher K. Patil,Arturo V. Orjalo,Francis Rodier,Gordon J. Lithgow,Judith Campisi +7 more
TL;DR: It is suggested that IL-1 receptor signaling initiates both miR-146a/b upregulation and cytokine secretion, and that miR/b is expressed in response to rising inflammatory cytokine levels as part of a negative feedback loop that restrains excessive SASP activity.
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Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Je-Hyun Yoon,Kotb Abdelmohsen,Jiyoung Kim,Xiaoling Yang,Jennifer L. Martindale,Kumiko Tominaga-Yamanaka,Elizabeth J.F. White,Arturo V. Orjalo,John L. Rinn,Stefan G. Kreft,Gerald M. Wilson,Myriam Gorospe +11 more
TL;DR: A post-translational function for the lncRNA HOTAIR is reported as an inducer of ubiquitin-mediated proteolysis, causing rapid decay of targets Ataxin-1 and Snurportin- 1, and preventing premature senescence.