Piers C. Emson

TL;DR: The production and characterization of a line of mice transgenic for the 383 aa isoform of human tau with the P301S mutation is reported on, with evidence for apoptosis obtained, despite the extensive colocalization of hyperphosphorylated tau protein with activated MAP kinase family members.

TL;DR: The presence of neuropeptide Y immunoreactive fibres in tracts such as the corpus callosum, anterior commissure, lateral olfactory tract, fimbria, medial corticohypothalamic tract, medial forebrain bundle, stria terminalis, dorsal periventricular bundle and other perivocentular areas indicated that in addition to the localisation of Neuropeptides Y-like peptide(s) in interneurons in the fore

TL;DR: The origins of neuropeptide Y-like immunoreactive (NPYI) fibers in the paraventricular and dorsomedial hypothalamic nuclei of the rat were examined using immunohistochemistry and destruction of the arcuate nucleus resulted in a marked decrease of NPYI fibers ipsilaterally in these nuclei.

TL;DR: It was found that all CCK-, SRIF-, and NPY-immunoreactive cells in cat cortex and 90%-95% in monkey cortex are also GluDCase positive, which implies that classes of cortical interneuron contain a conventional neurotransmitter (gamma-aminobutyric acid) and a neuromodulator (one of the peptides).

TL;DR: The characteristic telencephalic distribution of the neurones that contain VIP suggests a role for this peptide in cortical and limbic functions and some VIP-containing neurones probably also form long projections.