P
Pieter Demetter
Researcher at Université libre de Bruxelles
Publications - 74
Citations - 2684
Pieter Demetter is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Cirrhosis & Alcoholic liver disease. The author has an hindex of 25, co-authored 74 publications receiving 2235 citations.
Papers
More filters
Journal ArticleDOI
Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study
Thierry André,Armand de Gramont,Dewi Vernerey,Benoist Chibaudel,Franck Bonnetain,Annemilaï Tijeras-Raballand,Aurelie Scriva,Tamas Hickish,Josep Tabernero,Jean-Luc Van Laethem,Maria Banzi,E. Maartense,Einat Shacham Shmueli,Göran Carlsson,Werner Scheithauer,Demetris Papamichael,Marcus Möehler,Stefania Landolfi,Pieter Demetter,Soudhir Colote,Christophe Tournigand,Christophe Louvet,Alex Duval,Jean François Fléjou,Aimery de Gramont +24 more
TL;DR: The OS benefit of oxaliplatin-based adjuvant chemotherapy, increasing over time and with the disease severity, was confirmed at 10 years in patients with stage II to III colon cancer, and updated results support the use of FOLFOX in Patients with stage III disease, including those with dMMR or BRAF mutation.
Journal ArticleDOI
The interleukin-17 pathway is involved in human alcoholic liver disease
Arnaud Lemmers,Christophe Moreno,Thierry Gustot,Raphaël Maréchal,Delphine Degré,Pieter Demetter,Patricia de Nadai,Albert Geerts,Eric Quertinmont,Vincent Vercruysse,Olivier Le Moine,Jacques Devière +11 more
TL;DR: Human alcoholic liver disease is characterized by the activation of the IL‐ 17 pathway, and liver infiltration with IL‐17–secreting cell infiltrates is a key feature that might contribute to liver neutrophil recruitment.
Journal ArticleDOI
Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer.
TL;DR: This review applies the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan and Weinberg to re-explore the potential messages implicated in this process.
Journal ArticleDOI
Impaired Blood-Brain and Blood-Spinal Cord Barriers in Mutant SOD1-linked ALS Rat
Charles Nicaise,Dinko Mitrečić,Pieter Demetter,Robert De Decker,Michèle Authelet,Alain Boom,Roland Pochet +6 more
TL;DR: Electron microscopic data substantiate a toxic environment around endothelial cell and peri-vascular swollen astrocyte end-feet showing oedema-linked BBB opening and BBB/BSCB impairment was further substantiate by showing at symptomatic stages decreased mRNA expression of ZO-1 and occludin as well as agrin, a basal membrane constituent.
Journal ArticleDOI
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.
Eric Trepo,Thierry Gustot,Delphine Degré,Arnaud Lemmers,Laurine Verset,Pieter Demetter,Romy Ouziel,Eric Quertinmont,Vincent Vercruysse,Leila Amininejad,Pierre Deltenre,Olivier Le Moine,Jacques Devière,Denis Franchimont,Christophe Moreno +14 more
TL;DR: In European Caucasians, the rs738409 variant is associated with increased risk of ALD, liver damage, and cirrhosis and the potential of PNPLA3 as both a predictor and a therapeutic target in ALD is evaluated.