Showing papers in "Journal of Lipid Research in 1989"

TL;DR: Fish oil or linolenic acid may serve as alternative sources of long-chain n-3 FAs, but further studies will be needed to document their hypolipidemic and/or antiatherogenic effects.

TL;DR: The ability to estimate lipid peroxides of isolated low density lipoprotein was demonstrated and a stoichiometric relationship was observed between the amount of organic peroxide assayed and the concentration of iodine produced.

TL;DR: The derivation of a bile salt monomeric hydrophobicity index that quantitatively defines the composite hydrophilic-hydrophobic balance of a mixture of bile salts over a broad range of pH is described.

TL;DR: It is concluded that the apoB gene is constitutively expressed in HepG2 cells and that the mechanism of acute regulation of apiB production by these cells must involve co- or post-translational processes.

TL;DR: Results point to transepidermal water flux itself as the signal that regulates epidermal lipid synthesis, which is associated first with the redeposition of stratum corneum lipids and then the normalization of strata corneum barrier function.

TL;DR: A relationship between the total lipid content of the stratum corneum and barrier function is supported and removal of nonpolar species alone appears to cause only a modest level of barrier disruption, while removal of sphingolipids and free sterols leads to a more profoundlevel of barrier perturbation.

TL;DR: Longitudinal studies were carried out in the rabbit model to determine alterations in the concentration and density distribution of plasma lipids and apolipoproteins during the acute phase response (APR) characterized by elevated levels of C-reactive protein and serum amyloid A.

TL;DR: It is demonstrated for the first time that a relationship exists between the in vivo oxidation of lipoproteins in diabetes and the potential for tissue damage as monitored by in vitro cytotoxicity.

TL;DR: In the present study, acylhydrolase activity against C6NBD PC, PAF, and oxidized phosphatidylcholine copurfied through gel filtration and ion-exchange chromatography, suggesting that a single enzyme was active against all three substrates.

TL;DR: It is postulate that the changes in sitosterol metabolism (increased absorption, loss of tissue sterol structural recognition, expanded pools, and hepatic retention) are a response to reduced cholesterol synthesis in these subject.

TL;DR: In cell-free areas of WHHL and after only 10 days of cholesterol feeding, lipoprotein-derived lipid is present in the intima as clusters of vesicles enmeshed in the complex extracellular matrix.

TL;DR: HTGL may play a role in both the early estrogen-related changes in HDL triglyceride and apoE and the late estrogen- related changes in LDL cholesterol, apoA-I, and apOA-II, which persisted throughout the estrogen use.

TL;DR: Comparison of sequences from mouse, human, bovine, and guinea pig cDNAs indicated that the rates of evolution of mouse,human, andbovine LPL are quite low, but guinea Pig LPL has evolved several times faster than the others.

TL;DR: TNF is a potent inhibitor of LPL gene expression in human adipose tissue, and may play a role in the disorders of triglyceride catabolism and the pathogenesis of cachexia that occur with stimulation of the immune system in humans.

TL;DR: The potency of circulating bile salts as suppressors of the enzymes regulating bile acid and cholesterol synthesis increases with increasing hydrophobicity, and the hydrophobic-hydrophilic balance of the bile salt pool may play an important role in the regulation of cholesterol and bile Acid synthesis.

TL;DR: There was a dose-dependent decrease in the net accumulation of triglyceride-rich, apoB-containing lipoproteins and, to a lesser extent, cholesteryl esters and apoE and the inhibitory effect of insulin was partially abolished after a prolonged exposure of cells to insulin.

TL;DR: These studies demonstrate the successful development of an ELISA for Lp[a] protein that is insensitive to the presence of plasminogen; that heterogeneity of Lp,[a] and apo[a) are an important source of variation in the assay; and the need for an appropriate Lp.[a] standard in order to minimize this variation.

TL;DR: The results demonstrate major influence of both HL and LPL on serum HDL cholesterol concentration at a population level, and this appeared to be independent of the relative ponderosity by multiple correlation analysis.

TL;DR: CL 277,082 (I) was a potent inhibitor of cholesterol absorption in cholesterol-fed rats by markedly inhibiting increases in liver and serum cholesterol concentration while increasing the excretion of neutral 14C-labeled sterol in the feces.

TL;DR: This study aimed at redefining criteria for essential fatty acid (EFA) deficiency with the use of the direct transesterification procedure and determining whether a simple assay of total fatty acids (FA) is as predictive of EFA deficiency as the FA pattern from plasma, red cell, and platelet phospholipids.

TL;DR: TNF treatment of both male and female rats produces consistent increases in de novo hepatic lipogenesis in vivo under conditions that increase serum triglycerides, and it is unlikely that the limited effects of TNF on LPL in vivo can account for the rapid and sustained increase in serum cholesterol.

TL;DR: The fatty acids of egg yolk responded quickly to the hen's diet with most of the change occurring by 4 weeks and there was a linear relationship between the linolenic acid content of the diets and levels of this fatty acid in egg yolks and chick serum.

TL;DR: It is concluded that occupation of cell-surface receptors by HDL-E particles impairs platelet responsiveness to exogenous agonists and that platelet aggregability in the presence of whole HDL may reflect the relative concentrations of the individual subclasses in the particular sample.

TL;DR: High density lipoprotein binding to its receptor on cholesterol-loaded macrophages appears to promote translocation of intracellular cholesterol to the plasma membrane followed by cholesterol efflux into the medium, however, in nonloaded Macrophages, HDL stimulates sterol movement from the plasma membranes into intrACEllular pools by a receptor-independent process.

TL;DR: Data indicate that dietary polyunsaturated fat can selectively alter the expression of the apoA-I gene in a tissue-specific manner.

TL;DR: The comparison of gel filtration profiles of total serum and of serum fractions separated by ultracentrifugation showed that the apolipoprotein A-IV-high density lipoprotein association was a weak one, easily dissociated by the ultracentrating process.

TL;DR: Significant changes are demonstrated in the serum and urinary bile acid pattern in primary biliary cirrhosis during ursodeoxycholic acid treatment, which may be due to displacement of the more hydrophobic endogenous bile acids by the hydrophilic ursODEoxycholics acid.

TL;DR: In vitro findings suggest that the potent antioxidant property of probucol is directly related to the amount of drug in the LDL particle and may have relevance to its antiatherosclerotic effects observed in vivo.

TL;DR: The "esterase" activity of hormone-sensitive lipase (HSL) was studied using water-soluble p-nitrophenyl butyrate (PNPB) as a substrate and Diisopropylfluorophosphate strongly inhibited the HSL activities and the inhibition profiles of the triolein-; CO-, and PNPB-hydrolyzing activities were essentially identical.