Q
Qiming Liang
Researcher at Shanghai Jiao Tong University
Publications - 41
Citations - 2353
Qiming Liang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 17, co-authored 31 publications receiving 1696 citations. Previous affiliations of Qiming Liang include University of Southern California & Florida State University.
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Journal ArticleDOI
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.
Qiming Liang,Qiming Liang,Zhifei Luo,Jianxiong Zeng,Weiqiang Chen,Suan-Sin Foo,Shin-Ae Lee,Jianning Ge,Su Wang,Steven A. Goldman,Steven A. Goldman,Berislav V. Zlokovic,Zhen Zhao,Jae U. Jung +13 more
TL;DR: It is shown that ZIKV infection of human fetal neural stem cells (fNSCs) causes inhibition of the Akt-mTOR pathway, leading to defective neurogenesis and aberrant activation of autophagy, suggesting potential targets for anti-ZIKV therapeutic intervention.
Journal ArticleDOI
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.
Qiming Liang,Gil Ju Seo,Youn Jung Choi,Mi Jeong Kwak,Jianning Ge,Mary A. Rodgers,Mude Shi,Benjamin J. Leslie,Karl-Peter Hopfner,Taekjip Ha,Taekjip Ha,Byung-Ha Oh,Jae U. Jung +12 more
TL;DR: The cGAS-Beclin-1 interaction shapes innate immune responses by regulating both cGAMP production and autophagy, resulting in well-balanced antimicrobial immune responses.
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Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.
J. G. Li,Mingquan Guo,Xiaoxu Tian,Xin Wang,Xing Yang,Ping Wu,Chengrong Liu,Zixuan Xiao,Yafei Qu,Yue Yin,Chunxia Wang,Yucai Zhang,Zhaoqin Zhu,Zhenshan Liu,Chao Peng,Tongyu Zhu,Qiming Liang +16 more
TL;DR: This study presents a systematic examination of SARS-CoV-2-induced perturbation of host targets and cellular networks and reveals insights into the mechanisms by which Sars-Cov-2 triggers cytokine storms, representing a powerful resource in the pursuit for therapeutic intervention.
Journal ArticleDOI
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
Mary A. Rodgers,James W. Bowman,Hiroaki Fujita,Nicole I. Orazio,Mude Shi,Qiming Liang,Rina Amatya,Thomas J. Kelly,Kazuhiro Iwai,Jenny P.-Y. Ting,Jae U. Jung +10 more
TL;DR: Independent of its known role in NF-κB transcription, the HOIL-1L containing LUBAC is required for assembly and activation of the NLRP3 inflammasome via linear ubiquitination of ASC.
Journal ArticleDOI
Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7
Qiming Liang,Hongying Deng,Xiaojuan Li,Xianfang Wu,Qiyi Tang,Tsung-Hsien Chang,Hongzhuang Peng,Frank J. Rauscher,Keiko Ozato,Fanxiu Zhu +9 more
TL;DR: The identified tripartite motif-containing protein 28 (TRIM28) is identified as a binding partner of IRF7 and it is demonstrated that TRIM28 also interacts with the SUMO E2 enzyme and increases SUMOylation of IRf7 both in vivo and in vitro, suggesting it acts as asumO E3 ligase ofIRF7.