P
Pol Specenier
Researcher at University of Antwerp
Publications - 80
Citations - 3157
Pol Specenier is an academic researcher from University of Antwerp. The author has contributed to research in topics: Cetuximab & Head and neck cancer. The author has an hindex of 21, co-authored 77 publications receiving 2332 citations.
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Journal ArticleDOI
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study
Ezra E.W. Cohen,Denis Soulières,Christophe Le Tourneau,Christophe Le Tourneau,Christophe Le Tourneau,José Dinis,Lisa Licitra,Myung-Ju Ahn,Ainara Soria,Jean-Pascal Machiels,Jean-Pascal Machiels,Nicolas Mach,Ranee Mehra,Barbara Burtness,Pingye Zhang,Jonathan D. Cheng,Ramona F. Swaby,Kevin J. Harrington,Kevin J. Harrington,Mirelis Acosta-Rivera,Douglas Adkins,Morteza Aghmesheh,Mario Airoldi,Eduardas Aleknavicius,Yousuf Al-Farhat,Alain Algazi,Salah Almokadem,Anna Alyasova,Jessica Bauman,Marco Benasso,Alfonso Berrocal,Victoria Bray,Barbara Ann Burtness,F. Caponigro,Ana Castro,Terrence P. Cescon,Kelvin K. W. Chan,Arvind Chaudhry,Bruno Chauffert,Ezra W. Cohen,Tibor Csoszi,J. de Boer,Jean-Pierre Delord,Andreas Dietz,Charlotte Dupuis,Laurence Digue,Jozsef Erfan,Yolanda Alvarez,Mererid Evans,Mary J. Fidler,Martin David Forster,Signe Friesland,Apar Kishor Ganti,Lionnel Geoffrois,Cliona Grant,Viktor Gruenwald,Kevin J. Harrington,Thomas K. Hoffmann,Geza Horvai,Arturas Inciura,Raymond Woo-Jun Jang,Petra Jankowska,Antonio Jimeno,Mano Joseph,Alejandro Juarez Ramiro,Boguslawa Karaszewska,Andrzej Kawecki,Ulrich Keilholz,Ulrich Keller,Sung Bae Kim,Judit Kocsis,Nuria Kotecki,Mark F. Kozloff,Julio Lambea,Laszlo Landherr,Yuri Lantsukhay,Sergey Alexandrovich Lazarev,Lip Way Lee,Igor Dmitrievich Lifirenko,Danko Martincic,Oleg Vladmirovhich Matorin,Margaret McGrath,Krzysztof Misiukiewicz,John C. Morris,Fagim Fanisovich Mufazalov,Jiaxin Niu,Devraj Pamoorthy Srinivasan,Pedro Perez Segura,Daniel Rauch,Maria Leonor Ribeiro,Cristina P. Rodriguez,Frederic Rolland,Antonio Russo,Agnes Ruzsa,Frederico Sanches,Sang-Won Shin,Mikhail Shtiveland,Pol Specenier,Eva Szekanecz,Judit Szota,Carla M.L. van Herpen,Hector A. Velez-Cortes,William V. Walsh,Stefan Wilop,Ralph Winterhalder,Marek Z. Wojtukiewicz,Deborah Wong,Dan P. Zandberg +107 more
TL;DR: The clinically meaningful prolongation of overall survival and favourable safety profile of pembrolizumab in patients with recurrent or metastatic head and neck squamous cell carcinoma support the further evaluation of p embrolizUMab as a monotherapy and as part of combination therapy in earlier stages of disease.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
Journal ArticleDOI
A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
Alba A. Brandes,Antoine F. Carpentier,Santosh Kesari,Juan M. Sepúlveda-Sánchez,Helen Wheeler,Olivier Chinot,Lawrence Cher,Joachim P. Steinbach,David Capper,Pol Specenier,Jordi Rodon,Ann Cleverly,Claire Smith,Ivelina Gueorguieva,Colin Miles,Susan C. Guba,Durisala Desaiah,Michael Lahn,Wolfgang Wick +18 more
TL;DR: Galunisertib + lomustine failed to demonstrate improved OS relative to placebo + lmustine, and patients treated with galun isertib alone had fewer drug-related grade 3/4 adverse events compared with lomUSTine-treated patients.
Journal ArticleDOI
A Review of the Most Promising Biomarkers in Colorectal Cancer: One Step Closer to Targeted Therapy
TL;DR: An update of the most recent data on promising biological prognostic and/or predictive markers, including microsatellite instability, epidermal growth factor receptor, KRAS, BRAF, CpG island methylator phenotype, cytotoxic T lymphocytes, forkhead box P3-positive T cells, receptor for hyaluronic acid-mediated motility, phosphatase and tensin homolog, and T-cell originated protein kinase, in patients with CRC is provided.
Journal ArticleDOI
Programmed Cell Death-1 Inhibitor-Induced Type 1 Diabetes Mellitus.
TL;DR: It is essential that all clinicians are aware of diabetic ketoacidosis as a rare and life-threatening side effect of immunotherapy.