P
Pooja Verma
Researcher at Guru Nanak Dev University
Publications - 5
Citations - 199
Pooja Verma is an academic researcher from Guru Nanak Dev University. The author has contributed to research in topics: Indole test & Barbituric acid. The author has an hindex of 4, co-authored 5 publications receiving 181 citations.
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Journal ArticleDOI
Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads.
TL;DR: Dockings of two active molecules in the active sites of COX-2, thymidylate synthase and ribonucleotide reductase indicate their strong interactions with these enzymes.
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Dibutyltin(IV) complexes containing arylazobenzoate ligands: chemistry, in vitro cytotoxic effects on human tumor cell lines and mode of interaction with some enzymes.
Tushar S. Basu Baul,Anup Paul,Lorenzo Pellerito,Michelangelo Scopelliti,Palwinder Singh,Pooja Verma,Andrew Duthie,Dick de Vos,Edward R. T. Tiekink +8 more
TL;DR: Dibutyltin(IV) complexes of composition Bu2Sn(LH)2, where LH is a carboxylate residue derived from 2-[(E)-(5-tert-butyl-2-hydroxyphenyl)diazenyl]benzoate (L1H) with water molecule, were synthesized and characterized by spectroscopic (1H, 13C and 119Sn NMR, IR, 119Sn Mossbauer) techniques.
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Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: Synthesis, structure, biological efficacy and QSAR studies
Tushar S. Basu Baul,Anup Paul,Lorenzo Pellerito,Michelangelo Scopelliti,Claudia Pellerito,Palwinder Singh,Pooja Verma,Andrew Duthie,Dick de Vos,Rajeshwar P. Verma,Ulli Englert +10 more
TL;DR: Compared to cisplatin, test compounds 1-4 had remarkably good activity, despite the presence of substantial steric bulk due to Sn-Bu ligands, and the theoretical results are discussed in relation to the mechanistic role of the cytotoxic active test compounds (1-4).
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Triphenyltin(IV) 2-[( E )-2-(aryl)-1-diazenyl]benzoates as anticancer drugs: synthesis, structural characterization, in vitro cytotoxicity and study of its influence towards the mechanistic role of some key enzymes
Tushar S. Basu Baul,Anup Paul,Lorenzo Pellerito,Michelangelo Scopelliti,Palwinder Singh,Pooja Verma,Dick de Vos +6 more
TL;DR: Both the compounds are found to be far superior to CCDP, 5-FU (5-fluorouracil) and ETO (etoposide) across a panel of cell lines and the activity is more pronounced for the A498, EVSA-T, H226, IGROV, M19 MEL, MCF-7 and WIDR cell lines.
Journal ArticleDOI
Design, Synthesis and Anticancer Activities of Hybrids of Indole and Barbituric Acids — Identification of Highly Promising Leads.
TL;DR: By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized as discussed by the authors, and evaluated over 60 cell line panel of human cancer cells have identified two molecules with significant anticancer activities.