Prabhat Singh

TL;DR: In this paper , the authors provided a detailed transcriptional analysis of the three human monocyte subsets in healthy children and in children with dengue febrile illness, and found that the CD14+CD16high intermediate monocyte subset from dengUE patients highly upregulated key genes involved in mediating inflammation, endothelial dysfunction, vascular permeability, tissue extravasation, and clot prevention compared to healthy children.

TL;DR: It is indicated that a vast majority of the adults in India are immune to multiple dengue serotypes and show massive interindividual variation in neutralizing/binding antibodies and MBCs - emphasizing the importance of monitoring multiple parameters of immune memory in order to properly plan, evaluate and interpret d Dengue vaccines.

TL;DR: It is suggested that qualitative differences in the antibody response patterns that have evolved during the febrile phase can serve as biomarkers, that allow prediction of protection or progression to chronic arthritis in the future.

TL;DR: It is found that the CD69+IFNγ+ subset uniquely expressed key genes involved in protein translation, cellular metabolism, proliferation and dendritic cell cross talk, which provides valuable insights into the inherent diversity of the effector CD8 T cell response during dengue.