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Anmol Chandele
Researcher at Emory University
Publications - 33
Citations - 884
Anmol Chandele is an academic researcher from Emory University. The author has contributed to research in topics: Dengue fever & Dengue virus. The author has an hindex of 12, co-authored 33 publications receiving 618 citations. Previous affiliations of Anmol Chandele include International Centre for Genetic Engineering and Biotechnology.
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Rapid and massive virus specific plasmablast responses during acute dengue virus infection in humans
Jens Wrammert,Nattawat Onlamoon,Rama Akondy,Guey Chuen Perng,Korakot Polsrila,Anmol Chandele,Marcin Kwissa,Bali Pulendran,Patrick C. Wilson,Orasri Wittawatmongkol,Sutee Yoksan,Nasikarn Angkasekwinai,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Rafi Ahmed +14 more
TL;DR: Very potent plasmablast responses that often increased more than 1,000-fold over the baseline levels in healthy volunteers are found, raising the question as to whether these cells might have a role in dengue immunopathology during the ongoing infection.
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Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity
Mohit Singla,Meenakshi Kar,Tavpritesh Sethi,Sushil K. Kabra,Rakesh Lodha,Anmol Chandele,Guruprasad R. Medigeshi +6 more
TL;DR: Reduced interferon-α levels and enhanced aforementioned pro-inflammatory cytokines were identified as some of the distinctive markers of severe dengue, and the reduction in the levels of IL-8 and IL-10 were selected as the most significant markers of recovery from severe disease.
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Characterization of human CD8 T cell responses in dengue virus infected patients from India
Anmol Chandele,Jaturong Sewatanon,Jaturong Sewatanon,Sivaram Gunisetty,Mohit Singla,Nattawat Onlamoon,Rama Akondy,Haydn T. Kissick,Kaustuv Nayak,Elluri Seetharami Reddy,Haroon Kalam,Dhiraj Kumar,Anil Verma,Harekrushna Panda,Siyu Wang,Nasikarn Angkasekwinai,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Guruprasad R. Medigeshi,Rakesh Lodha,Sushil K. Kabra,Rafi Ahmed,Kaja Murali-Krishna +22 more
TL;DR: CD8 T cell subsets in dengue patients from India and Thailand are comprehensively characterized and it is revealed that these cells expand massively and express phenotypes indicative of overwhelming antigenic stimulus and tissue homing/cytotoxic-effector functions but that the vast majority of them fail to produce IFN-γ in vitro.
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Current status of therapeutic monoclonal antibodies against SARS-CoV-2.
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Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses.
Tarun Kumar Bhatt,Sameena Khan,Ved Prakash Dwivedi,Mudassir M. Banday,Arvind Sharma,Anmol Chandele,Noelia Camacho,Lluís Ribas de Pouplana,Yang Wu,Alister Craig,Antti Mikkonen,Alexander G. Maier,Manickam Yogavel,Amit Sharma +13 more
TL;DR: This work shows that parasite tyrosyl-tRNA synthetase (PfTyrRS), a housekeeping protein translation enzyme, induces pro-inflammatory responses from host immune cells, and describes it as a parasite-secreted protein that triggers pro- inflammatory host responses.