P
Prerana Dange
Researcher at Cancer Research Institute
Publications - 11
Citations - 382
Prerana Dange is an academic researcher from Cancer Research Institute. The author has contributed to research in topics: Cancer & Cytokeratin. The author has an hindex of 9, co-authored 9 publications receiving 329 citations. Previous affiliations of Prerana Dange include Tata Memorial Hospital.
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Journal ArticleDOI
Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype.
TL;DR: It appears that increased expression of CK8 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation.
Journal ArticleDOI
Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma
Hunain Alam,Amruta Bhate,Prakash Gangadaran,S. Sawant,Shimul Salot,Lalit Sehgal,Prerana Dange,Devendra Chaukar,Anil K. D'Cruz,Sadhna Kannanl,Rajiv P. Gude,Shubhada Kane,Sorab N. Dalal,Milind M. Vaidya +13 more
TL;DR: The results indicate that fascin promotes tumor progression and activates AKT and MAPK pathways in OSCC-derived cells and may prove to be useful in prognostication and treatment of OSCC.
Journal ArticleDOI
Understanding the Role of Keratins 8 and 18 in Neoplastic Potential of Breast Cancer Derived Cell Lines
Sapna V. Iyer,Prerana Dange,Hunain Alam,Sharada Sawant,Arvind Ingle,Anita M. Borges,Neelam Shirsat,Sorab N. Dalal,Milind M. Vaidya +8 more
TL;DR: The modulated K8 expression results indicate the role of K8/18 in modulating invasion in breast cancer - its presence correlating with less invasive phenotype and absence correlated with highly invasive, dedifferentiated phenotype.
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Prognostic role of Oct4, CD44 and c-Myc in radio-chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice
Sharada Sawant,Ravindran Caspa Gokulan,Harsh Dongre,Milind M. Vaidya,Devendra Chaukar,Kumar Prabhash,Arvind Ingle,Shriya Joshi,Prerana Dange,Shreyas Joshi,Archana K. Singh,Vidhi Makani,Shilpi Sharma,Ashok Jeyaram,Shubhada Kane,Anil K. D'Cruz +15 more
TL;DR: Oct4, c-Myc and CD44 can be used to predict local recurrence and the outcome of treatment in oral cancer patients and these molecules may find use as molecular targets for effective therapy.
Journal ArticleDOI
Clinical significance of aberrant vimentin expression in oral premalignant lesions and carcinomas.
S. Sawant,Milind M. Vaidya,Devendra Chaukar,Hunain Alam,Crismita Dmello,Prakash Gangadaran,Sadhana Kannan,S. V. Kane,Prerana Dange,N Dey,Kannan Ranganathan,Anil K. D'Cruz +11 more
TL;DR: Possible role of vimentin in early events of tobacco/areca nut-associated oral tumorigenesis is suggested, which may prove useful to predict the malignant potential of high-risk oral lesions.