P
Primo Baybayan
Researcher at Applied Biosystems
Publications - 4
Citations - 1516
Primo Baybayan is an academic researcher from Applied Biosystems. The author has contributed to research in topics: Shotgun sequencing & CpG site. The author has an hindex of 4, co-authored 4 publications receiving 1465 citations.
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Journal ArticleDOI
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
Giuseppe Pilia,Rhiannon M. Hughes-Benzie,Alex MacKenzie,Primo Baybayan,Ellson Y. Chen,Reid Huber,Giovanni Neri,Antonio Cao,Antonino Forabosco,David Schlessinger +9 more
TL;DR: To identify the causative gene, breakpoints in two female patients with X;autosome translocations were identified and initial western- and ligand-blotting experiments suggest that glypican 3 forms a complex with insulin-like growth factor 2 (IGF2), and might thereby modulate IGF2 action.
Journal ArticleDOI
X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein.
Juha Kere,Anand Srivastava,Outi Montonen,Jonathan Zonana,Nicholas Stuart Tudor Thomas,Betsy Ferguson,Felix Munoz,Delyth Morgan,Angus John Clarke,Primo Baybayan,Ellson Y. Chen,Sini Ezer,Ulpu Saarialho-Kere,Ulpu Saarialho-Kere,Albert de la Chapelle,David Schlessinger +15 more
TL;DR: The positional cloning of the gene mutated in EDA is described, which encode a predicted 135–residue transmembrane protein that may belong to a novel class with a role in epithelial–mesenchymal signalling.
Journal Article
Fine mapping of the EDA gene: a translocation breakpoint is associated with a CpG island that is transcribed.
Anand Srivastava,Outi Montonen,Ulpu Saarialho-Kere,E. Chen,Primo Baybayan,Johanna Pispa,J. Limon,David Schlessinger,Juha Kere +8 more
TL;DR: Results suggest that the CpG island just proximal of the AK translocation breakpoint lies at the 5' end of a candidate gene for EDA, a gene for human X-linked anhidrotic ectodermal dysplasia.
Journal ArticleDOI
Ordered Shotgun Sequencing of a 135 kb Xq25 YAC Containing ANT2 and Four Possible Genes, Including Three Confirmed by EST Matches
Chun-Nan Chen,Ying Su,Primo Baybayan,Aleli Siruno,Ramaiah Nagaraja,Richard Mazzarella,David Schlessinger,Ellson Y. Chen +7 more
TL;DR: Ordered shotgun sequencing has been successfully carried out with an Xq25 YAC substrate and the results suggest that OSS can be applied to YACs in accord with earlier simulations and indicate that the sequences of the YAC accurately reflects the sequence of uncloned human DNA.