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Nicholas Stuart Tudor Thomas
Researcher at Cardiff University
Publications - 78
Citations - 7477
Nicholas Stuart Tudor Thomas is an academic researcher from Cardiff University. The author has contributed to research in topics: Hypohidrotic ectodermal dysplasia & Mutation. The author has an hindex of 33, co-authored 74 publications receiving 6939 citations. Previous affiliations of Nicholas Stuart Tudor Thomas include University of Wales.
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Human Gene Mutation Database (HGMD): 2003 update.
Peter D. Stenson,Edward V. Ball,Matthew Mort,Andrew David Phillips,J. A. Shiel,Nicholas Stuart Tudor Thomas,Shaun S. Abeysinghe,Michael Krawczak,David Neil Cooper +8 more
TL;DR: Since its inception, HGMD has been expanded to include cDNA reference sequences for more than 87% of listed genes, splice junction sequences, disease‐associated and functional polymorphisms, as well as links to data present in publicly available online locus‐specific mutation databases.
Journal ArticleDOI
The Human Gene Mutation Database: 2008 update
Peter D. Stenson,Matthew Mort,Edward V. Ball,Katy Howells,Andrew David Phillips,Nicholas Stuart Tudor Thomas,David Neil Cooper +6 more
TL;DR: Although originally established for the scientific study of mutational mechanisms in human genes, HGMD has since acquired a much broader utility for researchers, physicians, clinicians and genetic counselors as well as for companies specializing in biopharmaceuticals, bioinformatics and personalized genomics.
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X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein.
Juha Kere,Anand Srivastava,Outi Montonen,Jonathan Zonana,Nicholas Stuart Tudor Thomas,Betsy Ferguson,Felix Munoz,Delyth Morgan,Angus John Clarke,Primo Baybayan,Ellson Y. Chen,Sini Ezer,Ulpu Saarialho-Kere,Ulpu Saarialho-Kere,Albert de la Chapelle,David Schlessinger +15 more
TL;DR: The positional cloning of the gene mutated in EDA is described, which encode a predicted 135–residue transmembrane protein that may belong to a novel class with a role in epithelial–mesenchymal signalling.
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Single base-pair substitutions in exon-intron junctions of human genes: nature, distribution, and consequences for mRNA splicing.
Michael Krawczak,Nicholas Stuart Tudor Thomas,Bernd Hundrieser,Matthew Mort,Michael Wittig,Jochen Hampe,David Neil Cooper +6 more
TL;DR: A meta‐analysis of 478 disease‐associated splicing mutations, in 38 different genes, reveals that exon skipping was the preferred phenotype when the immediate vicinity of the affected exon–intron junctions was devoid of alternative splice‐sites, and estimates that some 1.6% of disease‐causing missense substitutions in human genes are likely to affect the mRNA splicing phenotype.
Journal ArticleDOI
An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in Exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation
Meena Upadhyaya,Susan M Huson,M. Davies,Nicholas Stuart Tudor Thomas,Nadia Chuzhanova,S. Giovannini,D G R Evans,E. Howard,Bronwyn Kerr,Sian Wyn Griffiths,Claudia Consoli,Lucy Side,Darius J. Adams,Mary Ella M Pierpont,Rachel K. Hachen,A. Barnicoat,Hua Li,P. Wallace,J. P. Van Biervliet,David A. Stevenson,Dave Viskochil,Diana Baralle,Eric Haan,Vincent M. Riccardi,Peter D. Turnpenny,Conxi Lázaro,Ludwine Messiaen +26 more
TL;DR: These data represent results from the first study to correlate a specific small mutation of the NF1 gene to the expression of a particular clinical phenotype, and the biological mechanism that relates this specific mutation to the suppression of cutaneous neurofibroma development is unknown.