Prisca Ornaghi

TL;DR: The findings suggest that the Gcn5p bromodomain may discriminate between different acetylated lysine residues depending on the context in which they are displayed.

TL;DR: Starting from a yeast phenotypic screening performed on 21 compounds, the identification of two small molecules able to significantly reduce the S. cerevisiae cell growth, thus miming the effect of GCN5 deletion mutant is described.

TL;DR: A glutathione S-transferase pull down assay is used to show that Gcn5p binds the amino-terminal tails of histones H3 and H4, but not H2A and H2B, and suggests a new structural role for the highly evolutionary conserved bromodomain.

TL;DR: It is reported that the histone acetyltransferase Gcn5p is involved in cell cycle progression, whereas its absence induces several mitotic defects, including inefficient nuclear division, chromosome loss, delayed G2 progression, and spindle elongation.

TL;DR: The identification of MC1626 as a novel cell-permeable Gcn5p inhibitor suggests that it may be a very useful starting tool for the further development of new molecules to be applied to expression profiling of genes regulated by histone H3 acetylation.