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Patrizia Filetici
Researcher at Sapienza University of Rome
Publications - 54
Citations - 2048
Patrizia Filetici is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Acetylation & Histone acetyltransferase. The author has an hindex of 23, co-authored 52 publications receiving 1870 citations. Previous affiliations of Patrizia Filetici include University of Cagliari & National Research Council.
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Journal ArticleDOI
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
David J. Owen,Prisca Ornaghi,Ji-Chun Yang,Nicholas Lowe,Philip R. Evans,Paola Ballario,David Neuhaus,Patrizia Filetici,Andrew Travers +8 more
TL;DR: The findings suggest that the Gcn5p bromodomain may discriminate between different acetylated lysine residues depending on the context in which they are displayed.
Journal ArticleDOI
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties.
Antonello Mai,Dante Rotili,Domenico Tarantino,Prisca Ornaghi,Federica Tosi,Caterina Vicidomini,Gianluca Sbardella,Angela Nebbioso,Marco Miceli,Lucia Altucci,Patrizia Filetici +10 more
TL;DR: Starting from a yeast phenotypic screening performed on 21 compounds, the identification of two small molecules able to significantly reduce the S. cerevisiae cell growth, thus miming the effect of GCN5 deletion mutant is described.
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The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4
TL;DR: A glutathione S-transferase pull down assay is used to show that Gcn5p binds the amino-terminal tails of histones H3 and H4, but not H2A and H2B, and suggests a new structural role for the highly evolutionary conserved bromodomain.
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A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone.
Franco Chimenti,Bruna Bizzarri,Elias Maccioni,Daniela Secci,Adriana Bolasco,Paola Chimenti,Rossella Fioravanti,Arianna Granese,Simone Carradori,Federica Tosi,Paola Ballario,Stefano Vernarecci,Patrizia Filetici +12 more
TL;DR: The results demonstrate that CPTH2 is a novel HAT inhibitor modulating Gcn5p network in vitro and in vivo, and demonstrated a specific chemical-genetic interaction betweenCPTH2 and HAT GCN5p, indicating that CP TH2 inhibits the Gcn 5p dependent functional network.
Journal ArticleDOI
The Neurospora crassa White Collar-1 dependent blue light response requires acetylation of histone H3 lysine 14 by NGF-1.
Benedetto Grimaldi,Pierluca Coiro,Patrizia Filetici,Emanuela Berge,Joseph Dobosy,Michael Freitag,Eric U. Selker,Paola Ballario +7 more
TL;DR: In this article, it was shown that residue K14 of histone H3 associated with the light-inducible albino-3 (al-3) promoter becomes transiently acetylated after photoinduction.