Pritika Ramharack

TL;DR: This in silico ‘per-residue energy decomposition pharmacophore’ virtual screening approach will be critical in aiding scientists in the discovery of not only effective inhibitors of Zika viral targets, but also a wide range of anti-viral agents.

TL;DR: In this article, an optimized and proven screening technique was used in the discovery of two potential small molecule inhibitors of ZIKV Methyltransferase and RNA dependent RNA polymerase.

TL;DR: This study acts as a steppingstone toward the use of natural products against diseases that are plagued with adverse drug-interactions by examining the antiviral activity of these compounds against HIV-1 protease enzyme using computational tools.

TL;DR: The fundamental dynamic analysis presented in this report is crucial in understanding Zika NS3 helicase function, thereby giving insights toward an inhibition mechanism and may also assist in designing effective inhibitors against this detrimental viral target.

TL;DR: Experimental and molecular modelling approaches provided underpinning knowledge at the molecular level of the DOMP-polymer nanocrystal interactions and substantiated the experimental studies, including an understanding of the impact of polymers on the size of nanocrystals and their associated stability characteristics.