P
Pu-Ste Liu
Researcher at University of Lausanne
Publications - 8
Citations - 983
Pu-Ste Liu is an academic researcher from University of Lausanne. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 5, co-authored 5 publications receiving 494 citations. Previous affiliations of Pu-Ste Liu include National Health Research Institutes.
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Journal ArticleDOI
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu,Haiping Wang,Xiaoyun Li,Tung Chao,Tony Teav,Stefan Christen,Stefan Christen,Giusy Di Conza,Wan-Chen Cheng,Chih Hung Chou,Magdalena Vavakova,Charlotte Muret,Koen Debackere,Koen Debackere,Massimiliano Mazzone,Massimiliano Mazzone,Hsien Da Huang,Sarah-Maria Fendt,Sarah-Maria Fendt,Julijana Ivanisevic,Ping-Chih Ho +20 more
TL;DR: New mechanistic regulations by which glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming are revealed.
Journal ArticleDOI
Disturbed mitochondrial dynamics in CD8 + TILs reinforce T cell exhaustion
Yi-Ru Yu,Yi-Ru Yu,Hana Imrichova,Haiping Wang,Haiping Wang,Tung Chao,Tung Chao,Zhengtao Xiao,Min Gao,Marcela Rincon-Restrepo,Marcela Rincon-Restrepo,Fabien Franco,Fabien Franco,Raphael Genolet,Raphael Genolet,Wan-Chen Cheng,Wan-Chen Cheng,Camilla Jandus,Camilla Jandus,George Coukos,George Coukos,Yi-Fan Jiang,Jason W. Locasale,Alfred Zippelius,Alfred Zippelius,Pu-Ste Liu,Li Tang,Christoph Bock,Christoph Bock,Nicola Vannini,Nicola Vannini,Ping-Chih Ho,Ping-Chih Ho +32 more
TL;DR: It is reported that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction.
Journal ArticleDOI
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
Ping-Chih Ho,Pu-Ste Liu +1 more
TL;DR: Progress on immunometabolic regulations on fine-tuning activities of immune cells and how metabolic communication between cancer and infiltrating immune cells contributes to cancer immune evasion are reviewed.
Journal ArticleDOI
Mitochondria: A master regulator in macrophage and T cell immunity.
Pu-Ste Liu,Ping-Chih Ho +1 more
TL;DR: The mechanisms through which the mitochondrion acts as a master regulator to fine-tune immune responses elicited by macrophages and T cells are discussed.
Journal ArticleDOI
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Lydia N. Raines,Haoxin Zhao,Yuzhu Wang,Heng Chen,Héctor Gallart-Ayala,Pei-Chun Hsueh,Wei Cao,Yeojung Koh,Ana Alamonte-Loya,Pu-Ste Liu,Julijana Ivanisevic,Chan-Wang J. Lio,Ping-Chih Ho,Stanley Ching-Cheng Huang +13 more
TL;DR: Raines et al. as mentioned in this paper showed that the helper T cell 2 cytokine interleukin-4 and tumor microenvironment increase the activity of a protein kinase RNA-like ER kinase (PERK)-signaling cascade in macrophages and promote immunosuppressive M2 activation and proliferation.