Puppala Muthenna

TL;DR: The scope of adapting life-style modifications in the form of inclusion of certain common sources in the diet for the management of diabetic complications is indicated, as well as the importance of prevention of intracellular sorbitol accumulation.

TL;DR: The potential of some dietary components to prevent and/or inhibit protein glycation is indicated and these dietary agents may be able to be exploited for controlling AGE-mediated diabetic pathological conditions in vivo.

TL;DR: It is shown that curcumin inhibits ALR2 with an IC50 of 10 μM in a non‐competitive manner, but is a poor inhibitor of closely‐related members of the aldo‐keto reductase superfamily, particularly aldehyde reduct enzyme.

TL;DR: The antiglycating potential of EA is established and its in vivo utility in controlling AGE-mediated diabetic pathologies is established, as well as the effectiveness of EA against loss of eye lens transparency through inhibition of AGEs in the lens organ culture system.

TL;DR: Piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC(50) of 160 μM, and a series of analogues have been synthesized by modification of the styryl/aromatic and heterocyclic ring functionalities of this natural product lead.