J
Jun Wei
Researcher at St. Jude Children's Research Hospital
Publications - 29
Citations - 1737
Jun Wei is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 17, co-authored 28 publications receiving 1148 citations. Previous affiliations of Jun Wei include Nankai University & Peking Union Medical College.
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Journal ArticleDOI
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
Jun Wei,Lingyun Long,Kai Yang,Cliff Guy,Sharad Shrestha,Zuojia Chen,Chuan Wu,Peter Vogel,Geoffrey Neale,Douglas R. Green,Hongbo Chi +10 more
TL;DR: It is shown that autophagy is active in Treg cells and supports their lineage stability and survival fitness and Mechanistically, Autophagy deficiency upregulates metabolic regulators mTORC1 and c-Myc and glycolysis, which contribute to defective Treg function.
Journal ArticleDOI
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
Jun Wei,Lingyun Long,Wenting Zheng,Yogesh Dhungana,Seon Ah Lim,Cliff Guy,Yanyan Wang,Yong-Dong Wang,Chenxi Qian,Beisi Xu,Anil Kc,Jordy Saravia,Hongling Huang,Jiyang Yu,John G. Doench,Terrence L. Geiger,Hongbo Chi +16 more
TL;DR: It is demonstrated that, by targeting REGNASE-1, CD8+ T cells are reprogrammed to long-lived effector cells with extensive accumulation, better persistence and robust effector function in tumour immunity and point to avenues for improving the efficacy of adoptive cell therapy for cancer.
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The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol
TL;DR: Observations suggested that the hydrogel mainly composed of taxol would have great potential for its practical applications and might reduce side effects ofTaxol during chemotherapy.
Journal ArticleDOI
Lipid signalling enforces functional specialization of Treg cells in tumours
Seon Ah Lim,Jun Wei,Thanh-Long M. Nguyen,Hao Shi,Wei Su,Gustavo Palacios,Yogesh Dhungana,Nicole M. Chapman,Lingyun Long,Jordy Saravia,Peter Vogel,Hongbo Chi +11 more
TL;DR: In this article, the authors show that the activity of sterol-regulatory-element-binding proteins (SREBPs) is upregulated in intratumoral Treg cells and that deletion of SREBP-cleavage-activating protein (SCAP) in these cells inhibits tumour growth and boosts immunotherapy.
Journal ArticleDOI
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.
Presha Rajbhandari,Gonzalo Lopez,Gonzalo Lopez,Claudia Capdevila,Beatrice Salvatori,Jiyang Yu,Jiyang Yu,Ruth Rodriguez-Barrueco,Ruth Rodriguez-Barrueco,Daniel Martinez,Mark Yarmarkovich,Nina Weichert-Leahey,Brian J. Abraham,Mariano J. Alvarez,Archana Iyer,Jo Lynne Harenza,Derek A. Oldridge,Katleen De Preter,Jan Koster,Shahab Asgharzadeh,Shahab Asgharzadeh,Robert C. Seeger,Robert C. Seeger,Jun Wei,Javed Khan,Jo Vandesompele,Pieter Mestdagh,Rogier Versteeg,A. Thomas Look,Richard A. Young,Antonio Iavarone,Anna Lasorella,Jose Silva,John M. Maris,John M. Maris,Andrea Califano +35 more
TL;DR: A framework to determine the downstream effectors of the genetic alterations sustaining neuroblastoma subtypes is presented, which can be easily extended to other tumor types, and nominates TEAD4 as a novel candidate for therapeutic intervention.