Q
Qingzhan Zhang
Researcher at University of Illinois at Urbana–Champaign
Publications - 12
Citations - 634
Qingzhan Zhang is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Porcine reproductive and respiratory syndrome virus & Innate immune system. The author has an hindex of 9, co-authored 12 publications receiving 436 citations.
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Journal ArticleDOI
Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1.
TL;DR: PEDV modulates the host innate immune responses by degrading CBP and suppressing ISGs expression and it is demonstrated that the CBP degradation by nsp1 was proteasome-dependent.
Journal ArticleDOI
PRRS virus receptors and their role for pathogenesis.
Qingzhan Zhang,Dongwan Yoo +1 more
TL;DR: The advances and current understanding of the entry of PRRSV to cells are described with a particular focus on the role of CD163 and sialoadhesin for infection andPRRSV pathogenesis.
Journal ArticleDOI
Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling.
TL;DR: PEDV evasion of the type III IFN response in intestinal epithelial cells is shown for the first time, and it provides valuable information on host cell-virus interactions not only for PEDV but also for other enteric viral infections in swine.
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Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling
Qingzhan Zhang,Dongwan Yoo +1 more
TL;DR: A review of the recent understanding on the immune evasion strategies of porcine enteric coronaviruses and the role of different types of IFNs for intestinal antiviral innate immunity suggests that type III interferon plays a key role to maintain the antiviral state in the gut.
Journal ArticleDOI
Genomic characterization of emergent pseudorabies virus in China reveals marked sequence divergence: Evidence for the existence of two major genotypes.
Chao Ye,Qingzhan Zhang,Zhi-Jun Tian,Hao Zheng,Kuan Zhao,Fei Liu,Jin-Chao Guo,Wu Tong,Chenggang Jiang,Shujie Wang,Mang Shi,Xiao-Bo Chang,Yi-Feng Jiang,Jin-Mei Peng,Yan-Jun Zhou,Yan-Dong Tang,Ming-Xia Sun,Xuehui Cai,Tong-Qing An,Guangzhi Tong +19 more
TL;DR: Differences between HeN1 and Bartha strains may have been generated from long-term, independent evolution, which could explain the low efficacy of the Bartha vaccine in protecting pigs infected with genotype II PRV.