Qinxue Hu

TL;DR: It is described here how vaginal administration of the broadly neutralizing human monoclonal antibody b12 can protect macaques from simian-human immunodeficiency virus (SHIV) infection through the vagina, and observations support the concept that viral entry inhibitors can help prevent the sexual transmission of HIV-1 to humans.

TL;DR: The vaginal microbicide concept using the rhesus macaque ‘high dose’ vaginal transmission model with a CCR5-receptor-using simian–human immunodeficiency virus (SHIV-162P3) and three compounds that inhibit different stages of the virus–cell attachment and entry process is evaluated.

TL;DR: The evaluation of HIV-1 entry inhibitors for their ability to prevent infection of, and dissemination from, human cervical tissue ex vivo is described and the identification of the predominant receptors involved in HIV- 1 infection and dissemination withinhuman cervical tissue is highlighted.

TL;DR: It is demonstrated that CRISPR/Cas9 can efficiently mediate the editing of the C CR5 locus in cell lines, resulting in the knockout of CCR5 expression on the cell surface, and this is the first study establishing HIV-1 resistance in primary CD4(+) T-cells utilizing adenovirus-delivered CRISpr/ Cas9.

TL;DR: Data presented here indicate that targeting HIV envelope glycoproteins may provide an effective strategy to prevent HIV-1 infection mediated by either cell-free virus or infected cells.