Nanomedicine has offered new hope for cancer treatment.[1] Nanotherapeutics exhibit many advantages over small-molecule chemotherapeutics, including diminished systemic toxicity and improved circulation times. Unfortunately, non-uniformly leaky vasculature[2] and a dense interstitial structure[3] hinder their effective delivery to tumors.[4] These physiological abnormalities make transvascular transport—movement from vessels to the interstitium—and interstitial transport—movement through the interstitium to target cells—heterogeneous.[4a] Hence the tumor microenvironment limits the uniform penetration of nanotherapeutics by slowing or halting their transport through hydrodynamic and steric hindrance.[2a,3a,5] Overcoming these physiological barriers in tumors is an outstanding challenge for nanomedicine.

Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

Abstract Geomagnetic disturbances have affected electrical systems on the ground for over 150 years. The first effects were noted on the early telegraph in the 1840s and in this century magnetic storms have caused power system blackouts and phone system outages. Affected systems include all those that use electrical conductors: whether for transmission of power or signals or where the conducting properties are incidental to their use such as with pipelines and railway tracks. In power systems geomagnetically induced currents cause partial saturation of power transformers producing transformer heating and distortion of the ac waveform leading to misoperation of relays and other equipment. On pipelines, induced currents may contribute to corrosion but also present a problem with the electrical surveys of the pipe performed to monitor the corrosion prevention systems. Severity of these effects depends on disturbance size, proximity to the auroral zone, and the conductivity structure of the Earth. Also significant are system parameters such as the use of higher resistance coatings on pipelines and the linking of power systems into larger networks. In this paper we have attempted to catalogue all the published reports of geomagnetic effects on electrical systems and show their occurrence in the context of the solar cycle and geomagnetic activity variations for the years 1844 to 1996.

The Effects of Geomagnetic Disturbances on Electrical Systems at the Earth's Surface - An Update

Any design of nanoparticle vectors for cancer therapy or imaging must take into account the interaction of the nanoparticles with the tumor microenvironment. Size, charge, and shape have been shown to dominate this interaction.[1, 2] In vivo probing of solid tumors with particles of different sizes simultaneously has thus far been challenging due to the limitations of available nano-sized probes.[3–5] Fluorescent dextrans and other macromolecule probes have been used in studies with intravital microscopy, but heterogeneities across samples has prevented their use for the simultaneous imaging of a size series of probes within the same tumour.[5] MRI contrast agents are another attractive set of probes due to the minimally-invasive nature of the technology,[6, 7] but the lower spatial resolution of MRI limits the imaging of heterogeneity within tumors, and the technique does not allow for simultaneous imaging and tracking of a size series of probes within the same tumor.

A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Energy management of hybrid electric vehicles: A review of energy optimization of fuel cell hybrid power system based on genetic algorithm

Numerical modeling of superconductors is widely recognized as a powerful tool for interpreting experimental results, understanding physical mechanisms, and predicting the performance of high-temperature-superconductor (HTS) tapes, wires, and devices. This is particularly true for ac loss calculation since a sufficiently low ac loss value is imperative to make these materials attractive for commercialization. In recent years, a large variety of numerical models, which are based on different techniques and implementations, has been proposed by researchers around the world, with the purpose of being able to estimate ac losses in HTSs quickly and accurately. This paper presents a literature review of the methods for computing ac losses in HTS tapes, wires, and devices. Technical superconductors have a relatively complex geometry (filaments, which might be twisted or transposed, or layers) and consist of different materials. As a result, different loss contributions exist. In this paper, we describe the ways of computing such loss contributions, which include hysteresis losses, eddy-current losses, coupling losses, and losses in ferromagnetic materials. We also provide an estimation of the losses occurring in a variety of power applications.

Computation of Losses in HTS Under the Action of Varying Magnetic Fields and Currents

Electric vehicles (EVs) have recently been significantly developed in terms of both performance and drive range. There already are various models commercially available, and the number of EVs on road increases rapidly. Although most existing EVs are charged by electric cables, companies like Tesla, BMW and Nissan have started to develop wireless charged EVs that don’t require bulky cables. Rather than physical cable connection, the wireless (inductive) link effectively avoids sparking over plugging/unplugging. Furthermore, wireless charging opens new possibilities for dynamic charging – charging while driving. Once realised, EVs will no longer be limited by their electric drive range and the requirement for battery capacity will be greatly reduced. This has been prioritised and promoted worldwide, particularly in UK, Germany and Korea. This paper presents a thorough literature review on the wireless charging technology for EVs. The key technical components of wireless charging are summarised and compared, such as compensation topologies, coil design and communication. To enhance the charging power, an innovative approach towards the use of superconducting material in coil designs is investigated and their potential impact on wireless charging is discussed. In addition, health and safety concerns about wireless charging are addressed, as well as their relevant standards. Economically, the costs of a wide range of wireless charging systems has also been summarised and compared.

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A critical review on wireless charging for electric vehicles

Magnetic small-scale robots are devices of great potential for the biomedical field because of the several benefits of this method of actuation. Recent work on the development of these devices has seen tremendous innovation and refinement toward ​improved performance for potential clinical applications. This review briefly details recent advancements in small-scale robots used for biomedical applications, covering their design, fabrication, applications, and demonstration of ability, and identifies the gap in studies and the difficulties that have persisted in the optimization of the use of these devices. In addition, alternative biomedical applications are also suggested for some of the technologies that show potential for other functions. This study concludes that although the field of small-scale robot research is highly innovative ​there is need for more concerted efforts to improve functionality and reliability of these devices particularly in clinical applications. Finally, further suggestions are made toward ​the achievement of commercialization for these devices.

Micro/nanoscale magnetic robots for biomedical applications.

Electric vehicles (EVs) are limited by the on-board batteries in terms of driving range and charging duration. In this paper, the driving range of electric vehicles (EVs) charged by wireless power transfer (WPT) systems is investigated. Specifically, a force-based vehicle model is coupled with a simple extended battery model to simulate the impact of wireless charging on the state of charge of the accumulator sub-system. In total, three different scenarios, i.e., urban, highway and combined driving are presented. The trade-off between having a standalone charging option versus combined dynamic and quasi-dynamic wireless charging is outlined and minimum system requirements, such as charging power levels and road coverage, for unlimited range are established. Furthermore, the effect of external factors such as ambient temperature, battery age and wireless transfer efficiency is investigated. It is shown that employing combined charging at medium power levels is sufficient to achieve unlimited range compared to high power requirements for standalone charging. Finally, safety concerns regarding human exposure are addressed with lower charging powers.

Driving Range of Electric Vehicles Charged by Wireless Power Transfer

High-Tc superconducting (HTS)-coated conductors are a promising option for the next-generation power devices. However, their thin-film geometry incurs dynamic loss when exposed to a perpendicular external ac magnetic field, which is difficult to predicate and estimate. In this paper, we propose and verify a numerical simulation model to predict the dynamic loss in HTS-thin-coated conductors by taking into account their Jc-B dependence and I-V characteristics. The model has been tested on a SuperPower YBCO-coated conductor, and we observed a linear increase of dynamic loss along the increasing field amplitude after the threshold field. Our simulation results agree closely with experimental measurements as well as an analytical model. Furthermore, the model can predict the nonlinear increase of dynamic loss at high current, while the analytical model deviates from the measurement results and still shows a linear correlation between the dynamic loss and the external magnetic field. In addition, we have used this model to simulate the distributions of magnetic field and current density when dynamic loss occurs. Results clearly show the flux traversing the coated conductor, which causes dynamic loss. These distributions have also been used to analyze the change of dynamic loss when either the transport current or the magnetic field increase individually, while the other factor remains constant. The simulation analysis on dynamic loss is done for the first time in this paper, and our results clearly demonstrate how dynamic loss changes as well as its dependence on transport current and magnetic field.

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Numerical Modeling of Dynamic Loss in HTS-Coated Conductors Under Perpendicular Magnetic Fields

Dynamic resistance, which occurs when a HTS coated conductor carries a DC current under an AC magnetic field, can have critical implications for the design of HTS machines. Here, we report measurements of dynamic resistance in a commercially available SuperPower 4 mm-wide YBCO coated conductor, carrying a DC current under an applied AC magnetic field of arbitrary orientation. The reduced DC current, I t/I c0, ranged from 0.01 to 0.9, where I t is the DC current level and I c0 is the self-field critical current of the conductor. The field angle (the angle between the magnetic field and the normal vector of the conductor wide-face) was varied between 0° and 90° at intervals of 10°. We show that the effective width of the conductor under study is ~12% less than the physical wire width, and we attribute this difference to edge damage of the wire during or after manufacture. We then examine the measured dynamic resistance of this wire under perpendicular applied fields at very low DC current levels. In this regime we find that the threshold field, B th, of the conductor is well described by the nonlinear equation of Mikitik and Brandt. However, this model consistently underestimates the threshold field at higher current levels. As such, the dynamic resistance in a coated conductor under perpendicular magnetic fields is best described using two different equations for each of the low and high DC current regimes, respectively. At low DC currents where I t/I c0 ≤ 0.1, the nonlinear relationship of Mikitik and Brandt provides the closest agreement with experimental data. However, in the higher current regime where I t/I c0 ≥ 0.2, closer agreement is obtained using a simple linear expression which assumes a current-independent penetration field. We further show that for the conductor studied here, the measured dynamic resistance at different field angles is dominated by the perpendicular magnetic field component, with negligible contribution from the parallel component. Our findings now enable the dynamic resistance of a single conductor to be analytically determined for a very wide range of DC currents and at all applied field angles.

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Quan Li

Papers

A critical review on wireless charging for electric vehicles

Micro/nanoscale magnetic robots for biomedical applications.

Driving Range of Electric Vehicles Charged by Wireless Power Transfer

Numerical Modeling of Dynamic Loss in HTS-Coated Conductors Under Perpendicular Magnetic Fields

The dynamic resistance of YBCO coated conductor wire: Effect of DC current magnitude and applied field orientation