Qun Niu

TL;DR: Patients diagnosed with primary invasive breast cancer and with personal or family cancer history or tumor characteristics associated with high genetic risk for all classes of germline mutations in known breast cancer susceptibility genes are evaluated using a validated targeted capture and multiplex sequencing approach.

TL;DR: To improve breast cancer outcomes, it is suggested that family‐based models of risk assessment and genetic counseling coupled with interventions to reduce breast cancer risk should be broadly disseminated in Nigeria and other underserved and understudied populations.

TL;DR: This study highlights the complexity of applying current GWAS findings across racial/ethnic groups, as none of GWAS-identified index SNPs could be replicated in women of African ancestry.

TL;DR: Significant variations in UGT1A1 haplotype structure exist between African Americans and Caucasians in this relatively large cohort of women and have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry.

TL;DR: It has been reported that one biallelic missense mutation in the RAD51C gene was found in a Fanconi anemia-like disorder and six monoallelic pathogenic mutations were identified in 480 BRCA1/2 negative breast and ovarian cancer pedigrees but not in 620Pedigrees with breast cancer only.