Rachael B. Chanin

TL;DR: It is concluded that alterations of the gut microbiota, specifically a depletion of Clostridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infection.

TL;DR: This work identifies xenosiderophore utilization as a critical mechanism for B. thetaiotaomicron to sustain colonization during inflammation and suggests a mechanism of how interphylum iron metabolism contributes to gut microbiota resilience.

TL;DR: It is concluded that epithelial-derived reactive oxygen species are degraded in the gut lumen, which gives rise to molecular oxygen that supports the aerobic respiration of E. coli through AppBCX-mediated respiration in a catalase-dependent manner.

TL;DR: Investigation of transcriptional regulation of the respiratory l-lactate dehydrogenase LldD in vitro and in mouse models of Salmonella infection provides evidence that the host-derived metabolites oxygen and l- lactate serve as cues forSalmonella to regulate lactate oxidation metabolism on a transcriptional level.