R
Rachael B. Chanin
Researcher at University of Texas Southwestern Medical Center
Publications - 11
Citations - 323
Rachael B. Chanin is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Biology & Dysbiosis. The author has an hindex of 5, co-authored 6 publications receiving 201 citations.
Papers
More filters
Journal ArticleDOI
Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.
Caroline C. Gillis,Elizabeth R. Hughes,Luisella Spiga,Maria G. Winter,Wenhan Zhu,Tatiane Furtado de Carvalho,Rachael B. Chanin,Cassie L. Behrendt,Lora V. Hooper,Renato L. Santos,Sebastian E. Winter +10 more
TL;DR: It is concluded that alterations of the gut microbiota, specifically a depletion of Clostridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infection.
Journal ArticleDOI
Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis.
Wenhan Zhu,Maria G. Winter,Luisella Spiga,Elizabeth R. Hughes,Rachael B. Chanin,Aditi Mulgaonkar,Jenelle Pennington,Michelle Maas,Cassie L. Behrendt,Jiwoong Kim,Xiankai Sun,Daniel P. Beiting,Lora V. Hooper,Sebastian E. Winter +13 more
TL;DR: This work identifies xenosiderophore utilization as a critical mechanism for B. thetaiotaomicron to sustain colonization during inflammation and suggests a mechanism of how interphylum iron metabolism contributes to gut microbiota resilience.
Journal ArticleDOI
Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation.
Rachael B. Chanin,Maria G. Winter,Luisella Spiga,Elizabeth R. Hughes,Wenhan Zhu,Savannah J. Taylor,Alexandre Arenales,Caroline C. Gillis,Lisa Büttner,Angel G. Jimenez,Madeline P. Smoot,Renato L. Santos,Sebastian E. Winter +12 more
TL;DR: It is concluded that epithelial-derived reactive oxygen species are degraded in the gut lumen, which gives rise to molecular oxygen that supports the aerobic respiration of E. coli through AppBCX-mediated respiration in a catalase-dependent manner.
Journal ArticleDOI
Erratum: Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth (Cell Host & Microbe (2018) 23(1) (54–64.e6) (S1931312817305000) (10.1016/j.chom.2017.11.006))
Caroline C. Gillis,Elizabeth R. Hughes,Luisella Spiga,Maria G. Winter,Wenhan Zhu,Tatiane Furtado de Carvalho,Rachael B. Chanin,Cassie L. Behrendt,Lora V. Hooper,Renato L. Santos,Sebastian E. Winter +10 more
Journal ArticleDOI
Host-Derived Metabolites Modulate Transcription of Salmonella Genes Involved in l-Lactate Utilization during Gut Colonization
Caroline C. Gillis,Maria G. Winter,Rachael B. Chanin,Wenhan Zhu,Luisella Spiga,Sebastian E. Winter +5 more
TL;DR: Investigation of transcriptional regulation of the respiratory l-lactate dehydrogenase LldD in vitro and in mouse models of Salmonella infection provides evidence that the host-derived metabolites oxygen and l- lactate serve as cues forSalmonella to regulate lactate oxidation metabolism on a transcriptional level.