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Wenhan Zhu
Researcher at University of Texas Southwestern Medical Center
Publications - 38
Citations - 2004
Wenhan Zhu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Dysbiosis & Biology. The author has an hindex of 15, co-authored 29 publications receiving 1471 citations. Previous affiliations of Wenhan Zhu include Sun Yat-sen University & Purdue University.
Papers
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Journal ArticleDOI
Precision editing of the gut microbiota ameliorates colitis
Wenhan Zhu,Maria G. Winter,Mariana X. Byndloss,Luisella Spiga,Breck A. Duerkop,Elizabeth R. Hughes,Lisa Büttner,Everton de Lima Romão,Cassie L. Behrendt,Christopher A. Lopez,Luis Sifuentes-Dominguez,Kayci Huff-Hardy,R. Paul Wilson,R. Paul Wilson,Caroline C. Gillis,Çagla Tükel,Andrew Y. Koh,Ezra Burstein,Lora V. Hooper,Andreas J. Bäumler,Sebastian E. Winter +20 more
TL;DR: It is shown that a dysbiotic expansion of Enterobacteriaceae during gut inflammation could be prevented by tungstate treatment, which selectively inhibited molybdenum-cofactor-dependent microbial respiratory pathways that are operational only during episodes of inflammation.
Journal ArticleDOI
Comprehensive Identification of Protein Substrates of the Dot/Icm Type IV Transporter of Legionella pneumophila
Wenhan Zhu,Simran Banga,Yunhao Tan,Cheng Zheng,Rob Stephenson,Jonathan M. Gately,Zhao-Qing Luo +6 more
TL;DR: Sequence analysis of the C-termini of these identified proteins revealed that Lpg2844, which contains few features known to be important for Dot/Icm-dependent protein transfer can be translocated at a high efficiency.
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Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis
Elizabeth R. Hughes,Maria G. Winter,Breck A. Duerkop,Luisella Spiga,Tatiane Furtado de Carvalho,Wenhan Zhu,Caroline C. Gillis,Lisa Büttner,Madeline P. Smoot,Cassie L. Behrendt,Sara Cherry,Renato L. Santos,Lora V. Hooper,Sebastian E. Winter +13 more
TL;DR: Bacterial formate oxidation and oxygen respiration are identified as metabolic signatures for inflammation-associated dysbiosis, which is characterized by a reduced abundance of obligate anaerobic bacteria and an expansion of facultative Proteobacteria such as commensal E. coli.
Journal ArticleDOI
Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.
Caroline C. Gillis,Elizabeth R. Hughes,Luisella Spiga,Maria G. Winter,Wenhan Zhu,Tatiane Furtado de Carvalho,Rachael B. Chanin,Cassie L. Behrendt,Lora V. Hooper,Renato L. Santos,Sebastian E. Winter +10 more
TL;DR: It is concluded that alterations of the gut microbiota, specifically a depletion of Clostridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infection.
Journal ArticleDOI
Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity.
Tietao Wang,Meiru Si,Yunhong Song,Wenhan Zhu,Fen Gao,Yao Wang,Lei Zhang,Weipeng Zhang,Gehong Wei,Zhao-Qing Luo,Xihui Shen +10 more
TL;DR: The results assigned an unconventional role to T6SSs, which will lay the foundation for studying novel mechanisms of metal ion uptake by bacteria and the role of this process in their resistance to host immunity and survival in harmful environments.