L
Luisella Spiga
Researcher at University of Texas Southwestern Medical Center
Publications - 18
Citations - 1194
Luisella Spiga is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Dysbiosis & Gut flora. The author has an hindex of 10, co-authored 14 publications receiving 785 citations.
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Journal ArticleDOI
Precision editing of the gut microbiota ameliorates colitis
Wenhan Zhu,Maria G. Winter,Mariana X. Byndloss,Luisella Spiga,Breck A. Duerkop,Elizabeth R. Hughes,Lisa Büttner,Everton de Lima Romão,Cassie L. Behrendt,Christopher A. Lopez,Luis Sifuentes-Dominguez,Kayci Huff-Hardy,R. Paul Wilson,R. Paul Wilson,Caroline C. Gillis,Çagla Tükel,Andrew Y. Koh,Ezra Burstein,Lora V. Hooper,Andreas J. Bäumler,Sebastian E. Winter +20 more
TL;DR: It is shown that a dysbiotic expansion of Enterobacteriaceae during gut inflammation could be prevented by tungstate treatment, which selectively inhibited molybdenum-cofactor-dependent microbial respiratory pathways that are operational only during episodes of inflammation.
Journal ArticleDOI
Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis
Elizabeth R. Hughes,Maria G. Winter,Breck A. Duerkop,Luisella Spiga,Tatiane Furtado de Carvalho,Wenhan Zhu,Caroline C. Gillis,Lisa Büttner,Madeline P. Smoot,Cassie L. Behrendt,Sara Cherry,Renato L. Santos,Lora V. Hooper,Sebastian E. Winter +13 more
TL;DR: Bacterial formate oxidation and oxygen respiration are identified as metabolic signatures for inflammation-associated dysbiosis, which is characterized by a reduced abundance of obligate anaerobic bacteria and an expansion of facultative Proteobacteria such as commensal E. coli.
Journal ArticleDOI
Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.
Caroline C. Gillis,Elizabeth R. Hughes,Luisella Spiga,Maria G. Winter,Wenhan Zhu,Tatiane Furtado de Carvalho,Rachael B. Chanin,Cassie L. Behrendt,Lora V. Hooper,Renato L. Santos,Sebastian E. Winter +10 more
TL;DR: It is concluded that alterations of the gut microbiota, specifically a depletion of Clostridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infection.
Journal ArticleDOI
Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis
Franziska Faber,Parameth Thiennimitr,Luisella Spiga,Mariana X. Byndloss,Yael Litvak,Sara D. Lawhon,Helene Andrews-Polymenis,Sebastian E. Winter,Andreas J. Bäumler +8 more
TL;DR: The data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.
Journal ArticleDOI
An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.
Luisella Spiga,Maria G. Winter,Tatiane Furtado de Carvalho,Wenhan Zhu,Elizabeth R. Hughes,Caroline C. Gillis,Cassie L. Behrendt,Jiwoong Kim,Daniela Chessa,Helene Andrews-Polymenis,Daniel P. Beiting,Renato L. Santos,Lora V. Hooper,Sebastian E. Winter +13 more
TL;DR: It is shown that inflammation-derived electron acceptors induce a complete, oxidative TCA cycle in S. Typhimurium, allowing the bacteria to compete with the microbiota for colonization and to utilize a variety of carbon sources, including microbiota-derived succinate.