R
Rachael I. Scahill
Researcher at UCL Institute of Neurology
Publications - 161
Citations - 12555
Rachael I. Scahill is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Huntington's disease & Atrophy. The author has an hindex of 46, co-authored 145 publications receiving 10868 citations. Previous affiliations of Rachael I. Scahill include University College London Hospitals NHS Foundation Trust & University College London.
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Journal ArticleDOI
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.
Sarah J. Tabrizi,Douglas R. Langbehn,Blair R. Leavitt,Raymund A.C. Roos,Alexandra Durr,David Craufurd,Christopher Kennard,Stephen Hicks,Nick C. Fox,Rachael I. Scahill,Beth Borowsky,Allan J. Tobin,H. Diana Rosas,Hans J. Johnson,Ralf Reilmann,Bernhard Landwehrmeyer,Julie C. Stout,Julie C. Stout +17 more
TL;DR: The feasibility of rapid data acquisition and the use of multi-site 3T MRI and neurophysiological motor measures in a large multicentre study is shown, providing evidence for quantifiable biological and clinical alterations in HTT expansion carriers compared with age-matched controls.
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A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging.
Rachael I. Scahill,Chris Frost,Chris Frost,Rhian Jenkins,Jennifer L. Whitwell,Martin N. Rossor,Martin N. Rossor,Nick C. Fox +7 more
TL;DR: A significant age-associated decrease in global and regional brain volumes is found and some evidence indicates that this decline in brain volumes may be due to a nonlinear acceleration in rates of atrophy with increasing age.
Journal ArticleDOI
Huntington disease: natural history, biomarkers and prospects for therapeutics
Christopher A. Ross,Elizabeth Aylward,Edward J. Wild,Douglas R. Langbehn,Jeffrey D. Long,John H. Warner,Rachael I. Scahill,Blair R. Leavitt,Julie C. Stout,Jane S. Paulsen,R Reilmann,Paul G. Unschuld,Alice Wexler,Russell L. Margolis,Sarah J. Tabrizi +14 more
TL;DR: The natural history of HD is described, including the timing of emergence of motor, cognitive and emotional impairments, and the techniques that are used to assess these features, and potential future roles of these biomarkers in clinical trials are reviewed.
Journal ArticleDOI
Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data
Sarah J. Tabrizi,Rachael I. Scahill,Gail Owen,Alexandra Durr,Blair R. Leavitt,Raymund A.C. Roos,Beth Borowsky,Bernhard Landwehrmeyer,Chris Frost,Hans J. Johnson,David Craufurd,David Craufurd,R Reilmann,Julie C. Stout,Douglas R. Langbehn +14 more
TL;DR: In early HD, imaging, quantitative motor, and cognitive measures were predictive of decline in total functional capacity and tracked longitudinal change, and neuropsychiatric changes consistent with frontostriatal pathological abnormalities were associated with this loss of functional capacity.
Journal ArticleDOI
Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI
TL;DR: It is suggested that the sites showing the most significant rates of atrophy alter as the disease advances, and that regional atrophy is already occurring before the onset of symptoms.