Rachel A. O'Keefe

TL;DR: Treatments that target the IL-6/JAK/STAT3 pathway in patients with cancer are poised to provide therapeutic benefit by directly inhibiting tumour cell growth and by stimulating antitumour immunity.

TL;DR: Inhibition of bromodomain protein BRD4 represents a potential therapeutic strategy to circumvent the toxicities and financial burden of targeting the multiple receptor tyrosine kinases that drive cetuximab resistance in HNSCC and NSCLC.

TL;DR: It is reported that HPV(+) cell line- and patient-derived xenografts are resistant to PI3K inhibitors due to feedback signaling emanating from E6 and E7, and cross-talk between HER3 and HPV oncoproteins promotes resistance to PI2K inhibitors, suggesting cotargeting HER3-targeted therapies may be an effective therapeutic strategy in HPV(+ tumors.

TL;DR: In this article, a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and applying it to enhancing our understanding of head and neck squamous cell was proposed.

TL;DR: A ligation efficiency of nearly 95 percent is reported and the ligated CS3D demonstrated a half-life of 7.9 h in human serum, indicating adequate stability for intravenous delivery, and requisite biochemical characterization ofCS3D is provided that will inform upcoming clinical trials.