Rachel L. Belote

TL;DR: This article used a single-cell enrichment and RNA-sequencing pipeline to study human epidermal melanocytes directly from the skin, capturing transcriptomes across different anatomical sites, developmental age, sexes and multiple skin tones.

TL;DR: The characterization of human melanocytes fresh from skin revealed new subpopulations, human-specific transcriptional programs, and valuable insights into melanoma dedifferentiation.

TL;DR: Using differentiation programs delineated from healthy melanocytes, single cell RNA sequencing of freshly isolated human fetal, neonatal, and adult skin from a demographically diverse cohort revealed distinct subclasses of melanocytes from lineages that diverge early in human development.

TL;DR: In this article, the authors compared the transcriptomes of melanocytes from healthy human skin, nevi, and melanomas arising from nevi and identified a set of microRNAs as highly expressed nevus-enriched transcripts.

TL;DR: McNeal et al. as discussed by the authors used genetic approaches to study melanocytes from moles and melanomas and found that increasing the levels of two of these microRNAs in melanocyte from human skin stopped the cells from growing and dividing by inhibiting a gene called AURKB.