Rachel Legeron

TL;DR: In this article, the authors assessed whether augmented renal clearance (ARC) impacts negatively on antibiotic concentrations and clinical outcomes in patients treated by high-dose β-lactams administered continuously, and the performance of CLCr was assessed by a ROC curve, and multivariable logistic regression was performed to determine risk factors for subexposure and therapeutic failure.

TL;DR: Obese patients were more likely than nonobese patients to experience piperacillin underdosing when facing high minimal inhibitory concentration pathogens, and p Piperacillin drug monitoring might be necessary in the sickest patients who are at the highest risk of unpredictable plasma concentration exposing them to overdose, toxicity, underdoses, and treatment failure.

TL;DR: In this paper, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was proposed to quantify the plasmatic fraction of bevacizumab in human plasma.

TL;DR: A reliable and cost-effective LC-MS/MS method to quantify total plasmatic fraction of bevacizumab in human plasma and proposed a generic methodology easily transposable to quantify all IgG1 subclass very useful for clinical pharmacokinetics studies.

TL;DR: SC administration of ertapenem is an alternative to IV administration in older patients and is useful for the treatment of infections with ESBL-producing enterobacteria, as reported and compared.