R
Rachel M. Barry
Researcher at Massachusetts Institute of Technology
Publications - 4
Citations - 834
Rachel M. Barry is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Exome sequencing & Antigen. The author has an hindex of 4, co-authored 4 publications receiving 609 citations.
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Journal ArticleDOI
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
Viktor A. Adalsteinsson,Viktor A. Adalsteinsson,Gavin Ha,Gavin Ha,Samuel S. Freeman,Samuel S. Freeman,Atish D. Choudhury,Daniel G. Stover,Heather A. Parsons,Gregory Gydush,Sarah C. Reed,Denisse Rotem,Justin Rhoades,Denis Loginov,Denis Loginov,Dimitri Livitz,Daniel Rosebrock,Daniel Rosebrock,Ignaty Leshchiner,Jaegil Kim,Chip Stewart,Mara Rosenberg,Joshua M. Francis,Joshua M. Francis,Cheng-Zhong Zhang,Cheng-Zhong Zhang,Ofir Cohen,Ofir Cohen,Coyin Oh,Huiming Ding,Paz Polak,Paz Polak,Max Lloyd,Sairah Mahmud,Karla Helvie,Margaret S. Merrill,Rebecca A. Santiago,Edward P. O’Connor,Seong Ho Jeong,Rachel Leeson,Rachel M. Barry,Joseph F. Kramkowski,Zhenwei Zhang,Laura Polacek,Jens G. Lohr,Jens G. Lohr,Molly Schleicher,Emily Lipscomb,Andrea Saltzman,Nelly Oliver,Lori Marini,Adrienne G. Waks,Adrienne G. Waks,Lauren C. Harshman,Sara M. Tolaney,Eliezer M. Van Allen,Eric P. Winer,Nan Lin,Mari Nakabayashi,Mary-Ellen Taplin,Cory M. Johannessen,Levi A. Garraway,Todd R. Golub,Jesse S. Boehm,Nikhil Wagle,Nikhil Wagle,Gad Getz,Gad Getz,J. Christopher Love,J. Christopher Love,Matthew Meyerson +70 more
TL;DR: In this paper, a software called ichorCNA was proposed to quantitatively measure tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations.
Journal Article
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
Gavin Ha,Samuel S. Freeman,Atish D. Choudhury,Daniel G. Stover,Heather A. Parsons,Gregory Gydush,Sarah C. Reed,Denisse Rotem,Justin Rhoades,Dimitri Livitz,Daniel Rosebrock,Ignaty Leshchiner,Jaegil Kim,Chip Stewart,Mara Rosenberg,Joshua M. Francis,Cheng-Zhong Zhang,Ofir Cohen,Coyin Oh,Paz Polak,Max Lloyd,Sairah Mahmud,Karla Helvie,Margaret S. Merrill,Rebecca A. Santiago,Edward P. O’Connor,Seong Ho Jeong,Joseph F. Kramkowski,Zhenwei Zhang,Laura Polacek,Jens G. Lohr,Molly Schleicher,Emily Lipscomb,Andrea Saltzman,Nelly Oliver,Lori Marini,Adrienne G. Waks,Lauren C. Harshman,Sara M. Tolaney,Eliezer M. Van Allen,Eric P. Winer,Nan Lin,Mari Nakabayashi,Mary-Ellen Taplin,Cory M. Johannessen,Levi A. Garraway,Todd R. Golub,Jesse S. Boehm,Nikhil Wagle,Gad Getz,Matthew Meyerson,Viktor A. Adalsteinsson,Denis Loginov,Huiming Ding,Rachel Leeson,Rachel M. Barry,John C Love +56 more
TL;DR: The authors provide methods to identify patients eligible for comprehensive cfDNA profiling, revealing its applicability to many patients, and demonstrate high concordance of cfDNA and metastatic tumor whole-exome sequencing.
Journal ArticleDOI
Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture
Burak Dura,Mariah M. Servos,Rachel M. Barry,Hidde L. Ploegh,Stephanie K. Dougan,Joel Voldman +5 more
TL;DR: The utility of this microfluidic assay with natural killer cells interacting with tumor cells is demonstrated, and its findings suggest a possible role for the strength of early calcium signaling in selective coordination of subsequent cytotoxicity and IFN-gamma production.
Journal ArticleDOI
Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires.
Bin Jia,Lisa K. McNeil,Christopher D. Dupont,Konstantinos Tsioris,Rachel M. Barry,Ingrid L. Scully,Adebola O. Ogunniyi,Christopher C. Gonzalez,Michael W. Pride,Todd M. Gierahn,Paul A. Liberator,Kathrin U. Jansen,J. Christopher Love,J. Christopher Love +13 more
TL;DR: The results confirm that distinctive differences can manifest between antigen-specific memory B cell repertoires in nonhuman primates immunized with conjugated and unconjugated pneumococcal polysaccharide vaccines and supports the notion that the conjugations have a favorable profile in terms of both the frequency and breadth of the anamnestic response among antigen- specific memory B cells.