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Rachel Patton McCord
Researcher at University of Tennessee
Publications - 60
Citations - 5671
Rachel Patton McCord is an academic researcher from University of Tennessee. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 18, co-authored 50 publications receiving 4620 citations. Previous affiliations of Rachel Patton McCord include Oak Ridge National Laboratory & Harvard University.
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Journal ArticleDOI
Iterative correction of Hi-C data reveals hallmarks of chromosome organization
Maxim Imakaev,Geoffrey Fudenberg,Rachel Patton McCord,Natalia Naumova,Anton Goloborodko,Bryan R. Lajoie,Job Dekker,Leonid A. Mirny,Leonid A. Mirny +8 more
TL;DR: In this article, the authors present a pipeline that integrates a strategy for mapping of sequencing reads and a data-driven method for iterative correction of biases, yielding genome-wide maps of relative contact probabilities.
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Hi-C: a comprehensive technique to capture the conformation of genomes
TL;DR: In Hi-C, a biotin-labeled nucleotide is incorporated at the ligation junction, enabling selective purification of chimeric DNA ligation junctions followed by deep sequencing, and the compatibility of hi-C with next generation sequencing platforms makes it possible to detect chromatin interactions on an unprecedented scale.
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Condensin-driven remodelling of X chromosome topology during dosage compensation
Emily Crane,Qian Bian,Rachel Patton McCord,Bryan R. Lajoie,Bayly S. Wheeler,Edward J. Ralston,Satoru Uzawa,Job Dekker,Barbara J Meyer +8 more
TL;DR: This model implies that the DCC reshapes the topology of X chromosomes by forming new TAD boundaries and reinforcing weak boundaries through interactions between its highest-affinity binding sites, and deletion of an endogenous rex site at a DCC-dependent TAD boundary using CRISPR/Cas9 greatly diminished the boundary.
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Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations
Yu Zhang,Rachel Patton McCord,Yu-Jui Ho,Bryan R. Lajoie,Dominic G. Hildebrand,Alince C. Simon,Michael B. Becker,Frederick W. Alt,Job Dekker +8 more
TL;DR: A high-resolution Hi-C spatial organization map of the G1-arrested mouse pro-B cell genome is generated and high-throughput genome-wide translocation sequencing is used to map translocations from target DNA double-strand breaks (DSBs) within it.
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High-resolution DNA-binding specificity analysis of yeast transcription factors
Cong Zhu,Kelsey J. R. P. Byers,Rachel Patton McCord,Zhenwei Shi,Michael F. Berger,Daniel E. Newburger,Katrina Saulrieta,Katrina Saulrieta,Zachary A. Smith,Zachary A. Smith,Mita V. Shah,Mita V. Shah,Mathangi Radhakrishnan,Mathangi Radhakrishnan,Anthony A. Philippakis,Yanhui Hu,Federico De Masi,Marcin Pacek,Andreas Rolfs,T. V. S. Murthy,Joshua LaBaer,Martha L. Bulyk +21 more
TL;DR: High-resolution binding profiles for 89 known and predicted yeast TFs are determined and proteins that bind the PAC (Polymerase A and C) motif (GATGAG) and regulate ribosomal RNA transcription and processing, core cellular processes that are constituent to ribosome biogenesis are discovered.