F
Federico De Masi
Researcher at Technical University of Denmark
Publications - 39
Citations - 2454
Federico De Masi is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 17, co-authored 36 publications receiving 1988 citations. Previous affiliations of Federico De Masi include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
High-resolution DNA-binding specificity analysis of yeast transcription factors
Cong Zhu,Kelsey J. R. P. Byers,Rachel Patton McCord,Zhenwei Shi,Michael F. Berger,Daniel E. Newburger,Katrina Saulrieta,Katrina Saulrieta,Zachary A. Smith,Zachary A. Smith,Mita V. Shah,Mita V. Shah,Mathangi Radhakrishnan,Mathangi Radhakrishnan,Anthony A. Philippakis,Yanhui Hu,Federico De Masi,Marcin Pacek,Andreas Rolfs,T. V. S. Murthy,Joshua LaBaer,Martha L. Bulyk +21 more
TL;DR: High-resolution binding profiles for 89 known and predicted yeast TFs are determined and proteins that bind the PAC (Polymerase A and C) motif (GATGAG) and regulate ribosomal RNA transcription and processing, core cellular processes that are constituent to ribosome biogenesis are discovered.
Journal ArticleDOI
Systematic discovery of new recognition peptides mediating protein interaction networks.
Victor Neduva,Rune Linding,Isabelle Su-Angrand,Alexander Stark,Federico De Masi,Toby J. Gibson,Joe Lewis,Luis Serrano,Robert B. Russell +8 more
TL;DR: The approach based on motif over-representation in non-homologous sequences, rediscovers known motifs and predicts dozens of others that will give molecular insight into protein networks and greatly illuminate cellular processes.
Systematic Discovery of New Recognition Peptides Mediating Protein Interaction
Networks Neduva,Rune Linding,Isabelle Su-Angrand,Alexander Stark,Federico De Masi,Toby J. Gibson,Joe Lewis,Luis Serrano,Robert B. Russell +8 more
TL;DR: In this paper, a method based on motif over-representation in non-homologous sequences was proposed to detect linear motifs, which can explain how one protein is able to bind to very different partners.
Journal ArticleDOI
A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors
Christian A. Grove,Federico De Masi,M. Inmaculada Barrasa,Daniel E. Newburger,Mark J. Alkema,Martha L. Bulyk,Martha L. Bulyk,Albertha J.M. Walhout +7 more
TL;DR: This work comprehensively identifies dimerization partners, spatiotemporal expression patterns, and DNA-binding specificities for the C. elegans bHLH family of TFs, and model these data into an integrated network that displays both specificity and promiscuity, as some b HLH proteins, DNA sequences, and tissues are highly connected, whereas others are not.
Journal ArticleDOI
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Lasse Folkersen,Stefan Gustafsson,Qin Wang,Qin Wang,Daniel Hvidberg Hansen,Åsa K Hedman,Åsa K Hedman,Andrew J. Schork,Andrew J. Schork,Karen Page,Daria V. Zhernakova,Yang Wu,James E. Peters,Niclas Eriksson,Sarah E Bergen,Thibaud Boutin,Andrew D. Bretherick,Stefan Enroth,Anette Kalnapenkis,Jesper R. Gådin,Bianca E. Suur,Yan Chen,Ljubica Perisic Matic,Jeremy D. Gale,Julie Lee,Weidong Zhang,Amira Quazi,Mika Ala-Korpela,Seung Hoan Choi,Annique Claringbould,John Danesh,George Davey Smith,Federico De Masi,Sölve Elmståhl,Gunnar Engström,Eric B. Fauman,Céline Fernandez,Lude Franke,Paul W. Franks,Vilmantas Giedraitis,Chris Haley,Anders Hamsten,Andres Ingason,Åsa Johansson,Peter K. Joshi,Lars Lind,Cecilia M. Lindgren,Steven A. Lubitz,Steven A. Lubitz,Tom Palmer,Erin Macdonald-Dunlop,Martin Magnusson,Olle Melander,Karl Michaëlsson,Andrew P. Morris,Reedik Mägi,Michael W. Nagle,Peter M. Nilsson,Jan Nilsson,Marju Orho-Melander,Ozren Polasek,Bram P. Prins,Erik Pålsson,Ting Qi,Marketa Sjögren,Johan Sundström,Johan Sundström,Praveen Surendran,Urmo Võsa,Thomas Werge,Rasmus Wernersson,Harm-Jan Westra,Jian Yang,Alexandra Zhernakova,Johan Ärnlöv,Jingyuan Fu,J. Gustav Smith,Tõnu Esko,Tõnu Esko,Caroline Hayward,Ulf Gyllensten,Mikael Landén,Agneta Siegbahn,James F. Wilson,James F. Wilson,Lars Wallentin,Adam S. Butterworth,Michael V. Holmes,Michael V. Holmes,Erik Ingelsson,Anders Mälarstig,Anders Mälarstig +91 more
TL;DR: The utility of large-scale mapping of the genetics of the proteome is demonstrated and pQTLs are provided as a resource for future precision studies of circulating proteins in human health.