Rachel Yehuda

TL;DR: In this paper, inspired by the plenary panel at the 2013 meeting of the International Society for Traumatic Stress Studies, Steven Southwick and multidisciplinary panelists tackle some of the most pressing current questions in the field of resilience research including how do the authors define resilience, what are the most important determinants of resilience, and how are new technologies informing the science of resilience?

TL;DR: Sensitivity of the HPA axis is consistent with the clinical picture of hyperreactivity and hyperresponsiveness in PTSD, and the reduction in cortisol levels results from an enhanced negative feedback by cortisol, which is secondary to an increased sensitivity of glucocorticoid receptors in target tissues.

TL;DR: In this review, what is known about the clinical and biological characteristics of PTSD is summarized and some of the gaps in knowledge that can be addressed by basic neuroscience research are articulated.

TL;DR: The data suggest that effects of maternal PTSD related to cortisol can be observed very early in the life of the offspring and underscore the relevance of in utero contributors to putative biological risk for PTSD.

TL;DR: The pattern of cortisol secretion and regulation observed in the PTSD group under baseline conditions may reflect an exaggerated sensitization, whereas the chronobiological alterations in depression may reflect dysregulation, of the hypothalamic-pituitary-adrenal (HPA) axis.