R
Radhakrishna Rao
Researcher at University of Tennessee Health Science Center
Publications - 87
Citations - 5923
Radhakrishna Rao is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Tight junction & Occludin. The author has an hindex of 38, co-authored 83 publications receiving 5292 citations. Previous affiliations of Radhakrishna Rao include Medical University of South Carolina & University of Tennessee.
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Endotoxemia and Gut Barrier Dysfunction in Alcoholic Liver Disease
TL;DR: Evidence indicates that intestinal microflora, the metabolism of ethanol, and acetaldehyde-induced cell signaling are involved in ethanol-induced intestinal barrier dysfunction, which is the main cause of endotoxemia in ALD.
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Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.
TL;DR: Results show that oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosinesine-kinase-dependent mechanism.
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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
TL;DR: These studies demonstrate that probiotic-secretory proteins protect the intestinal epithelial tight junctions and the barrier function from hydrogen peroxide-induced insult by a PKC- and MAP kinase-dependent mechanism.
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Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
TL;DR: A significant body of evidence indicates that endotoxemia and endotoxin-mediated hepatocellular damage play a crucial role in the pathogenesis of alcoholic liver disease.
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Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences: Summary of a Symposium
Vishnudutt Purohit,J. Christian Bode,Christiane Bode,David A. Brenner,Mashkoor A. Choudhry,Frank A. Hamilton,Y. James Kang,Ali Keshavarzian,Radhakrishna Rao,R. Balfour Sartor,Christine A. Swanson,Jerrold R. Turner +11 more
TL;DR: Reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries.