R
Rafael Pineda
Researcher at University of Córdoba (Spain)
Publications - 42
Citations - 3254
Rafael Pineda is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: Kisspeptin & Gonadotropin secretion. The author has an hindex of 26, co-authored 40 publications receiving 2945 citations. Previous affiliations of Rafael Pineda include Carlos III Health Institute.
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Journal ArticleDOI
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
Antonia K. Roseweir,Alexander S. Kauffman,Jeremy Troy Smith,Kathryn A. Guerriero,Kevin Morgan,Justyna Pielecka-Fortuna,Rafael Pineda,Michelle L. Gottsch,Manuel Tena-Sempere,Suzanne M. Moenter,Ei Terasawa,Iain J. Clarke,Robert A. Steiner,Robert P. Millar +13 more
TL;DR: The development of kisspeptin antagonists provides a valuable tool for investigating the physiological and pathophysiological roles ofkisspeptin in the regulation of reproduction and could offer a unique therapeutic agent for treating hormone-dependent disorders of reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer.
Journal ArticleDOI
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Juan Carlos Roa,E. Vigo,Rafael Pineda,Carlos Dieguez,Enrique Aguilar,Leonor Pinilla,Manuel Tena-Sempere +9 more
TL;DR: This observation, together with the ability of exogenous kisspeptin to rescue defective LH responses in diabetic rats, unravel the physiopathological implication, and potential therapeutic intervention, of the KiSS-1 system in altered gonadotropin secretion of type 1 diabetes.
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Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.
Víctor M. Navarro,Juan M. Castellano,Sarah M. McConkey,Rafael Pineda,Francisco Ruiz-Pino,Leonor Pinilla,Donald K. Clifton,Manuel Tena-Sempere,Robert A. Steiner +8 more
TL;DR: Observations suggest that NKB/NK3R signaling in Kiss1/NKB/Dyn-producing neurons in the Arc has a pivotal role in the control of gonadotropin-releasing hormone (GnRH)/LH secretion and its regulation by E(2)-dependent negative feedback in the rat.
Journal ArticleDOI
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Alicia Felip,Silvia Zanuy,Rafael Pineda,Leonor Pinilla,Manuel Carrillo,Manuel Tena-Sempere,Ana M. Gómez +6 more
TL;DR: The data are the first to provide conclusive evidence for the existence of a second KiSS gene, KiSS-2, in non-placental vertebrates, whose product is likely to play a dominant stimulatory role in the regulation of the gonadotropic axis at least in teleosts.
Journal ArticleDOI
Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist.
Rafael Pineda,David Garcia-Galiano,Antonia K. Roseweir,M. Romero,Miguel A. Sánchez-Garrido,Francisco Ruiz-Pino,Kevin Morgan,Leonor Pinilla,Robert P. Millar,Manuel Tena-Sempere +9 more
TL;DR: The data document the validity of p234 for antagonizing Kp actions in vivo and provide direct experimental evidence for the important role of Kp signaling in the key events of female reproduction, such as puberty onset and the preovulatory surge of gonadotropins.