R
Rafael S. Depetris
Researcher at Cornell University
Publications - 11
Citations - 1596
Rafael S. Depetris is an academic researcher from Cornell University. The author has contributed to research in topics: Insulin receptor & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 9, co-authored 11 publications receiving 1527 citations. Previous affiliations of Rafael S. Depetris include New York University.
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Journal ArticleDOI
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
Robert Pejchal,Katie J. Doores,Katie J. Doores,Laura M. Walker,Reza Khayat,Po-Ssu Huang,Sheng-Kai Wang,Robyn L. Stanfield,Jean-Philippe Julien,Alejandra Ramos,Matthew Crispin,Rafael S. Depetris,Umesh Katpally,Andre Marozsan,Albert Cupo,Sebastien M. Maloveste,Yan Liu,Ryan McBride,Yukishige Ito,Rogier W. Sanders,Cassandra Ogohara,James C. Paulson,Ten Feizi,Christopher N. Scanlan,Chi-Huey Wong,John P. Moore,William C. Olson,Andrew B. Ward,Pascal Poignard,Pascal Poignard,William R. Schief,William R. Schief,Dennis R. Burton,Dennis R. Burton,Ian A. Wilson +34 more
TL;DR: The data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.
Journal ArticleDOI
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Jean-Philippe Julien,Devin Sok,Reza Khayat,Jeong Hyun Lee,Katherine Doores,Laura M. Walker,Alejandra Ramos,Devan Diwanji,Robert Pejchal,Albert Cupo,Umesh Katpally,Rafael S. Depetris,Robyn L. Stanfield,Ryan McBride,Andre J. Marozsan,James C. Paulson,Rogier W. Sanders,John P. Moore,Dennis R. Burton,Pascal Poignard,Andrew B. Ward,Ian A. Wilson +21 more
TL;DR: Structural, functional and biophysical results suggest that the PGT121 antibodies may interfere with Env receptor engagement by an allosteric mechanism in which key structural elements, such as the V3 base, the N332 oligomannose glycan and surrounding glycans, including a putative V1/V2 complex biantennary glycan, are conformationally constrained.
Journal ArticleDOI
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures
Audray K. Harris,Mario J. Borgnia,Dan Shi,Alberto Bartesaghi,Haifeng He,Robert Pejchal,Yun Kenneth Kang,Rafael S. Depetris,Andre Marozsan,Rogier W. Sanders,Per Johan Klasse,Jacqueline L. S. Milne,Ian A. Wilson,William C. Olson,John P. Moore,Sriram Subramaniam +15 more
TL;DR: It is demonstrated that soluble gp140 trimers can be designed to mimic the quaternary structural transitions displayed by native trimeric Env on the surface of intact HIV-1 virions.
Journal ArticleDOI
Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Rafael S. Depetris,Junjie Hu,Ilana Gimpelevich,Loweanna J Holt,Roger J. Daly,Stevan R. Hubbard +5 more
TL;DR: The crystal structure of the Grb14 BPS region in complex with the tyrosine kinase domain of the insulin receptor reveals that the N-terminal portion of the B PS region binds as a pseudosubstrate inhibitor in the substrate peptide binding groove of the kinase.
Journal ArticleDOI
Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
Per Johan Klasse,Rafael S. Depetris,Robert Pejchal,Jean-Philippe Julien,Reza Khayat,Reza Khayat,Jeong Hyun Lee,Andre J. Marozsan,Albert Cupo,Nicolette Cocco,Jacob Korzun,Anila Yasmeen,Andrew B. Ward,Ian A. Wilson,Rogier W. Sanders,Rogier W. Sanders,John P. Moore +16 more
TL;DR: Methods to improve the properties of soluble, cleaved gp140 trimers of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) for use in structural studies and as immunogens are described.