Rafael Tejada

TL;DR: It is reported that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production, and progenitor-active chemokines offer a new strategy to restore hematopoiesis in a clinical setting.

TL;DR: Functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34+ and mouse Lin−Sca-1+c-Kit+ BM-repopulating stem cells, conveying signals for recruitment of HSCs and reconstitution of hematopoiesis.

TL;DR: Two fully human anti-KDR antibodies are produced, from Fab fragments originally isolated from a large antibody phage display library, that strongly inhibited VEGF-induced migration of human leukemia cells in vitro, and when administered in vivo, significantly prolonged survival of NOD-SCID mice inoculated withhuman leukemia cells.

TL;DR: Functional vascular endothelial growth factor receptor‐1 (VEGFR1, Flt‐1) is expressed on a subpopulation of human and mouse Lin−Sca‐1+c‐Kit+ BM‐repopulating stem cells, conveying signals for recruitment of HSCs and reconstitution of hematopoietic recovery.

TL;DR: Preliminary data suggest that hematopoietic stem cells express only one AC133 isoform and four allelic variants in the AC133-P1 promoter, which differ by the number of short tandem repeats as well as by a single nucleotide polymorphism (SNP), might lay a foundation for testing a risk of susceptibility to AC133+ leukemias.