K
Koji Shido
Researcher at Cornell University
Publications - 39
Citations - 10205
Koji Shido is an academic researcher from Cornell University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 25, co-authored 38 publications receiving 9076 citations. Previous affiliations of Koji Shido include Howard Hughes Medical Institute & Seton Hall University.
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Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
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Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.
Scott T. Avecilla,Koichi Hattori,Beate Heissig,Rafael Tejada,Francesca-Fang Liao,Koji Shido,David K. Jin,Sergio Dias,Fan Zhang,Travis Hartman,Neil R. Hackett,Ronald G. Crystal,Larry Witte,Daniel J. Hicklin,Peter Bohlen,Dan L. Eaton,David Lyden,Fredric De Sauvage,Shahin Rafii +18 more
TL;DR: It is reported that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production, and progenitor-active chemokines offer a new strategy to restore hematopoiesis in a clinical setting.
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Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Bi-Sen Ding,Daniel J. Nolan,Jason M. Butler,Daylon James,Alexander O. Babazadeh,Zev Rosenwaks,Vivek Mittal,Hideki Kobayashi,Koji Shido,David Lyden,Thomas N. Sato,Sina Y. Rabbany,Sina Y. Rabbany,Shahin Rafii +13 more
TL;DR: It is shown that inducible genetic ablation of vascular endothelial growth factor (VEGF)-A receptor-2 (VEGFR2) in the LSECs impairs the initial burst of hepatocyte proliferation and subsequent reconstitution of the hepatovascular mass by inhibiting upregulation of the endothelial-cell-specific transcription factor Id1, which suggests an instructive vascular niche in the early phases of physiological liver regeneration.
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Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
David K. Jin,Koji Shido,Hans-Georg Kopp,Isabelle Petit,Sergey V. Shmelkov,Lauren M. Young,Andrea T. Hooper,Hideki Amano,Scott T. Avecilla,Beate Heissig,Koichi Hattori,Fan Zhang,Daniel J. Hicklin,Yan Wu,Zhenping Zhu,Ashley R. Dunn,Hassan Salari,Zena Werb,Neil R. Hackett,Ronald G. Crystal,David Lyden,Shahin Rafii +21 more
TL;DR: Hematopoietic cytokines, through graded deployment of SDF-1 from platelets, support mobilization and recruitment of CXCR4+VEGFR1+ hemangiocytes, whereas VEGFR1 is essential for their angiogenic competency for augmenting revascularization.
Journal ArticleDOI
Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
Jason M. Butler,Daniel J. Nolan,Eva L. Vertes,Barbara Varnum-Finney,Hideki Kobayashi,Andrea T. Hooper,Marco Seandel,Marco Seandel,Koji Shido,Ian A. White,Mariko Kobayashi,Larry Witte,Chad May,Carrie J. Shawber,Yuki Kimura,Jan Kitajewski,Zev Rosenwaks,Irwin D. Bernstein,Shahin Rafii +18 more
TL;DR: Angiogenic models are developed to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic LT-HSCs, and establish an instructive vascular niche for clinical-scale expansion of LT- HSCs and a cellular platform to identify stem cell-active trophogens.