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Alessandro Borsatti
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 12
Citations - 3730
Alessandro Borsatti is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Chemokine receptor & CCR1. The author has an hindex of 11, co-authored 12 publications receiving 3663 citations.
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Journal ArticleDOI
Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s
Raffaella Bonecchi,Giancarlo Bianchi,Paola Panina Bordignon,Daniele D’Ambrosio,Rosmarie Lang,Alessandro Borsatti,Silvano Sozzani,Paola Allavena,Patrick Gray,Alberto Mantovani,Francesco Sinigaglia +10 more
TL;DR: T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which produce large amounts of IL-4 and IL-5 upregulate IgE production and are prominent in the pathogenesis of allergic diseases.
Journal Article
Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines.
Silvano Sozzani,Walter Luini,Alessandro Borsatti,Nadia Polentarutti,Dan Zhou,Lorenzo Piemonti,Giovanna D'Amico,Christine A. Power,Timothy N. C. Wells,Marco Gobbi,Paola Allavena,Alberto Mantovani +11 more
TL;DR: Among hemopoietic elements, DC respond to a unique set of CC and CXC chemokines, and their responsiveness is restricted to migration with no effect on Ag capture and presentation.
Journal ArticleDOI
Bacterial Lipopolysaccharide Rapidly Inhibits Expression of C-C Chemokine Receptors in Human Monocytes
Antonio Sica,Alessandra Saccani,Alessandro Borsatti,Christine A. Power,Timothy N. C. Wells,Walter Luini,Nadia Polentarutti,Silvano Sozzani,Alberto Mantovani +8 more
TL;DR: Results suggest that, regulation of receptor expression in addition to agonist production is likely a crucial point in the regulation of the chemokine system.
Journal ArticleDOI
Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes
Silvano Sozzani,Silvia Ghezzi,Gioacchino Iannolo,Walter Luini,Alessandro Borsatti,Nadia Polentarutti,Antonio Sica,Massimo Locati,Charles R. Mackay,Timothy N. C. Wells,Priscilla Biswas,Elisa Vicenzi,Guido Poli,Alberto Mantovani +13 more
TL;DR: IL-10–stimulated monocytes are more efficiently infected by HIV BaL and add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.
Journal Article
Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils
Raffaella Bonecchi,Nadia Polentarutti,Walter Luini,Alessandro Borsatti,Sergio Bernasconi,Massimo Locati,Christine A. Power,Amanda E. I. Proudfoot,Timothy N. C. Wells,Charles R. Mackay,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani +12 more
TL;DR: The results suggest that the selectivity of certain chemokines for their target cells may be altered by cytokines produced within an inflammatory context.