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Ali J. Marian
Researcher at University of Texas at Austin
Publications - 221
Citations - 15848
Ali J. Marian is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Hypertrophic cardiomyopathy & Cardiomyopathy. The author has an hindex of 60, co-authored 221 publications receiving 13890 citations. Previous affiliations of Ali J. Marian include Baylor University & St Lukes Episcopal Hospital.
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Journal ArticleDOI
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.
Tomasz J. Guzik,Tomasz J. Guzik,Saidi A Mohiddin,Anthony Dimarco,Vimal Patel,K Savvatis,Federica M. Marelli-Berg,Meena S. Madhur,Maciej Tomaszewski,Pasquale Maffia,Pasquale Maffia,Fulvio D'Acquisto,Stuart A. Nicklin,Ali J. Marian,Ryszard Nosalski,Ryszard Nosalski,Eleanor Murray,Bartłomiej Guzik,Colin Berry,Rhian M. Touyz,Reinhold Kreutz,Dao Wen Wang,David Bhella,Orlando Sagliocco,Filippo Crea,E. Thomson,Iain B. McInnes +26 more
TL;DR: While ACE2 is essential for viral invasion, there is no evidence that ACE inhibitors or angiotensin receptor blockers (ARBs) worsen prognosis, Hence, patients should not discontinue their use.
Journal ArticleDOI
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Ali J. Marian,Eugene Braunwald +1 more
TL;DR: The routine applications of genetic testing and preclinical identification of family members represents an important advance and enhanced understanding of the molecular pathogenesis of HCM and have stimulated efforts designed to identify new therapeutic agents.
Journal ArticleDOI
Tissue Doppler Imaging Consistently Detects Myocardial Abnormalities in Patients With Hypertrophic Cardiomyopathy and Provides a Novel Means for an Early Diagnosis Before and Independently of Hypertrophy
Sherif F. Nagueh,Linda L. Bachinski,Denise Meyer,Rita Hill,William A. Zoghbi,James W. Tam,James W. Tam,Miguel A. Quinones,Robert Roberts,Ali J. Marian +9 more
TL;DR: Myocardial contraction and relaxation velocities, detected by TD imaging, are reduced in FHCM, including in those without LVH, and TD imaging is an accurate and sensitive method for identifying subjects who are positive for F HCM mutations.
Journal ArticleDOI
Suppression of canonical Wnt/β-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
Eduardo Garcia-Gras,Raffaella Lombardi,Michael J. Giocondo,James T. Willerson,Michael D. Schneider,Dirar S. Khoury,Ali J. Marian +6 more
TL;DR: It is shown that cardiac-restricted deletion of Dsp, encoding DP, impairs cardiac morphogenesis and leads to high embryonic lethality in the homozygous state, which provides for a novel molecular mechanism for the pathogenesis of ARVC.
Journal ArticleDOI
Identification of a Genetic Locus for Familial Atrial Fibrillation
Ramon Brugada,Terry Tapscott,Grazyna Czernuszewicz,Ali J. Marian,Anna Iglesias,Lluís Mont,Josep Brugada,Josep Girona,Anna Domingo,Linda L. Bachinski,Robert Roberts +10 more
TL;DR: Identification of the gene for familial atrial fibrillation will help to elucidate the molecular basis of the disease and provide insights into acquired forms and should accelerate the process of gene mapping in the future.