R
Raffaella Soldi
Researcher at Maine Medical Center
Publications - 49
Citations - 2857
Raffaella Soldi is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Cancer & Cancer research. The author has an hindex of 24, co-authored 40 publications receiving 2716 citations. Previous affiliations of Raffaella Soldi include Mario Negri Institute for Pharmacological Research & University of Utah.
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Journal ArticleDOI
Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2
Raffaella Soldi,Stefania Mitola,Marina Strasly,Paola Defilippi,Guido Tarone,Federico Bussolino +5 more
TL;DR: A new role for αvβ3 integrin is indicated in the activation of an in vitro angiogenic program in endothelial cells by participating in the full activation of VEGFR‐2 triggered by VEGF‐A, which is an importantAngiogenic inducer in tumors, inflammation and tissue regeneration.
Journal ArticleDOI
The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.
Adriana Albini,Raffaella Soldi,Daniela Giunciuglio,Enrico Giraudo,Roberto Benelli,Luca Primo,Douglas M. Noonan,Mariolina Salio,Giovanni Camussi,Wolfang Rockl,Federico Bussolino +10 more
TL;DR: It is demonstrated that HIV–1 Tat specifically binds and activates the Flk–1/kinase insert domain receptor (Flk-1/KDR), a VEGF–A tyrosine kinase receptor, and that Tat–induced angiogenesis is blocked by agents blocking the FlK–1-KDR receptor.
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Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development
Adam M. Gustafson,Raffaella Soldi,Christina Anderlind,Mary Beth Scholand,Jun Qian,Xiaohui Zhang,Kendal G. Cooper,Darren Walker,Annette McWilliams,Gang Liu,Eva Szabo,Jerome S. Brody,Pierre P. Massion,Marc E. Lenburg,Marc E. Lenburg,Stephen Lam,Andrea H. Bild,Avrum Spira,Avrum Spira +18 more
TL;DR: D deregulation of the PI3K pathway in the bronchial airway epithelium of smokers is an early, measurable, and reversible event in the development of lung cancer and that genomic profiling of these relatively accessible airway cells may enable personalized approaches to chemoprevention and therapy.
Journal ArticleDOI
The non-classical export routes: FGF1 and IL-1α point the way
Igor Prudovsky,Anna Mandinova,Raffaella Soldi,Cinzia Bagalà,Irene Graziani,Matteo Landriscina,Francesca Tarantini,Maria F. Duarte,Stephen Bellum,Holly Doherty,Thomas Maciag +10 more
TL;DR: Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence, and inhibition of their export by Cu2+ chelators is an effective strategy for treatment of several diseases.
Journal ArticleDOI
Secretion without Golgi
Igor Prudovsky,Francesca Tarantini,Matteo Landriscina,David J. Neivandt,Raffaella Soldi,Aleksandr Kirov,Deena Small,Karuppanan Muthusamy Kathir,Dakshinamurthy Rajalingam,Thallapuranam Krishnaswamy Suresh Kumar +9 more
TL;DR: Non‐classical release of FGF1 and IL1α presents a promising target for treatment of cardiovascular, oncologic, and inflammatory disorders.