Showing papers by "Rainer Breitling published in 2016"
TL;DR: The application of synthetic biology approaches to the engineering of monoterpene/monoterpenoid production is reviewed, highlighting the discovery of novel catalytic building blocks, their accelerated assembly into functional pathways, general strategies for product diversification, and new methods for the optimization of productivity to economically viable levels.
85 citations
TL;DR: Bioinformatics tools facilitate and accelerate all steps along the Design–Build–Test cycle of synthetic biology, for the enhanced production of natural products in engineered microbes.
51 citations
TL;DR: The current state of the field is discussed, highlighting recent advances and remaining bottlenecks, and global genomic assessments of natural product biosynthetic capacities across large parts of microbial diversity are provided.
Abstract: The diversity and natural modularity of their biosynthetic pathways has turned natural products into attractive, but challenging, targets for synthetic biology approaches Here, we discuss the current state of the field, highlighting recent advances and remaining bottlenecks Global genomic assessments of natural product biosynthetic capacities across large parts of microbial diversity provide a first survey of the available natural parts libraries and identify evolutionary design rules for further engineering Methods for compound and pathway detection and characterization are developed increasingly on the basis of synthetic biology tools, contributing to an accelerated translation of genomic information into usable building blocks for pathway assembly A wide range of methods is also becoming available for accessing ever larger parts of chemical space by rational diversification of natural products, guided by rapid progress in our understanding of the underlying biochemistry and enzymatic mechanisms Enhanced genome assembly and editing tools, adapted to the needs of natural products research, facilitate the realization of ambitious engineering strategies, ranging from combinatorial library generation to high-throughput optimization of product titers Together, these tools and concepts contribute to the emergence of a new generation of revitalized natural product research
27 citations
30 Sep 2016
TL;DR: A surprisingly large number of European spider species have never been reliably rediscovered since their first description many decades ago, and most of these are probably synonymous with other species or unidentifiable, due to insufficient descriptions or missing type material.
Abstract: A surprisingly large number of European spider species have never been reliably rediscovered since their first description many decades ago. Most of these are probably synonymous with other species or unidentifiable, due to insufficient descriptions or missing type material. In this second part of a series on this topic, we discuss about 100 of these cases, focusing mainly on species described in the early 20th century by Pelegrín Franganillo Balboa and Gabor von Kolosváry, as well as a number of jumping spiders and various miscellaneous species. In most cases, the species turned out to be unidentifiable nomina dubia, but for some of them new synonymies could be established as follows: Alopecosa accentuata auct., nec (Latreille, 1817) = Alopecosa farinosa (Herman, 1879) syn. nov., comb. nov.; Alopecosa barbipes oreophila Simon, 1937 = Alopecosa farinosa (Herman, 1879) syn. nov., comb. nov.; Alopecosa mariae orientalis (Kolosváry, 1934) = Alopecosa mariae (Dahl, 1908) syn. nov.; Araneus angulatus afolius (Franganillo, 1909) and Araneus angulatus atricolor Simon, 1929 = Araneus angulatus Clerck, 1757 syn. nov.; Araneus angulatus castaneus (Franganillo, 1909) = Araneus pallidus (Olivier, 1789) syn. nov.; Araneus angulatus levifolius (Franganillo, 1909), Araneus angulatus niger (Franganillo, 1918) and Araneus angulatus nitidifolius (Franganillo, 1909) = Araneus angulatus Clerck, 1757 syn. nov.; Araneus angulatus pallidus (Franganillo, 1909), Araneus angulatus crucinceptus (Franganillo, 1909), Araneus angulatus fuscus (Franganillo, 1909) and Araneus angulatus iberoi (Franganillo, 1909) = Araneus pallidus (Olivier, 1789) syn. nov.; Araneus circe strandi (Kolosváry, 1935) = Araneus circe (Audouin, 1826) syn. nov.; Araneus diadematus nemorosus Simon, 1929 and Araneus diadematus soror (Simon, 1874) = Araneus diadematus Clerck, 1757 syn. nov.; Araneus pyrenaeus (Simon, 1874) = Araneus pallidus (Olivier, 1789) syn. nov.; Araneus sericinus (Roewer, 1942) = Aculepeira armida (Audouin, 1826) syn. nov.; Arctosa brevialva (Franganillo, 1913) = Arctosa villica (Lucas, 1846) syn. nov.; Arctosa cinerea (Franganillo, 1913) [nec Arctosa cinerea (Fabricius, 1777)] = Arctosa perita (Latreille, 1799) syn. nov.; Cresmatoneta eleonorae (Costa, 1883) and Cresmatoneta mutinensis orientalis (Strand, 1914) = Cresmatoneta mutinensis (Canestrini, 1868) syn. nov.; Cyclosa conica albifoliata Strand, 1907, Cyclosa conica defoliata Strand, 1907, Cyclosa conica leucomelas Strand, 1907, Cyclosa conica pyrenaica Strand, 1907, Cyclosa conica dimidiata Simon, 1929, Cyclosa conica rubricauda Simon, 1929 and Cyclosa conica triangulifera Simon, 1929 = Cyclosa conica (Pallas, 1772) syn. nov.; Dendryphantes lanipes C.L. Koch, 1846 = Philaeus chrysops (Poda, 1761) syn. nov.; Diplocephalus alpinus strandi Kolosváry, 1937 = Diplocephalus alpinus (O. PickardCambridge, 1872) syn. nov.; Entelecara strandi Kolosváry, 1934 = Nusoncus nasutus (Schenkel, 1925) syn. nov.; Euophrys rosenhaueri L. Koch, 1856 = Menemerus semilimbatus (Hahn, 1829) syn. nov.; Evarcha falcata nigrofusca (Strand, 1900) = Evarcha falcata (Clerck, 1757) syn. nov.; Gibbaranea bituberculata strandiana (Kolosváry, 1936) = Gibbaranea bituberculata (Walckenaer, 1802) syn. nov.; Heliophanus auratus mediocinctus Kulczyński, 1898 = H. mediocinctus Kulczyński, 1898 stat. nov.; Larinioides sclopetarius jacobea (Franganillo, 1910) = Larinioides sclopetarius (Clerck, 1757) syn. conf.; Linyphia triangularis juniperina Kolosváry, 1933 = Linyphia triangularis (Clerck, 1757) syn. nov.; Myrmarachne formicaria tyrolensis (C. L. Koch, 1846) = Myrmarachne formicaria (De Geer, 1778) syn. conf.; Nuctenea umbratica obscura (Franganillo, 1909) = Nuctenea umbratica (Clerck, 1757) syn. nov.; Ozyptila strandi Kolosváry, 1939 = Ozyptila confluens (C. L. Koch, 1845) syn. nov.; Panamomops strandi Kolosváry, 1934 = Saloca diceros (O. Pickard-Cambridge, 1871) syn. nov.; Pardosa luctinosa marina (Kolosváry, 1940) and Pardosa luctinosa etsinensis Schenkel, 1963 = Pardosa luctinosa Simon, 1876 syn. nov.; Pardosa wagleri atra (Giebel, 1869) nomen oblitum = Pardosa saturatior Simon, 1937 syn. nov.; Poecilochroa hungarica Kolosváry, 1934 = Aphantaulax trifasciata (O. Pickard-Cambridge, 1872) syn. nov.; Philaeus albovariegatus (Simon, 1868) = Philaeus chrysops (Poda, 1761) syn. nov.; Philaeus superciliosus Bertkau, 1883 = Sandalodes superbus (Karsch, 1878) syn. nov.; Philaeus varicus (Simon, 1868) = Carrhotus xanthogramma (Latreille, 1819) syn. conf.; Salticus unispinus (Franganillo, 1910) = Pellenes nigrociliatus (Simon, 1875) syn. nov.; Sitticus manni (Doleschall, 1852) nomen oblitum = Heliophanus melinus L. Koch, 1867 syn. nov.; Sitticus sexsignatus (Franganillo, 1910) = Sitticus floricola (C. L. Koch, 1837) syn. nov.; Steatoda latrodectoides (Franganillo, 1913) = Steatoda paykulliana (Walckenaer, 1805) syn. nov.; Synema globosum clarum Franganillo, 1913, Synema globosum flavum Franganillo, 1913 and Synema globosum pulchellum Franganillo, 1926 = Synema globosum (Fabricius, 1775) syn. nov.; Uloborus pseudacanthus Franganillo, 1910 = Uloborus walckenaerius Latreille, 1806 syn. nov.; Zelotes similis hungaricus Kolosváry, 1944 = Zelotes similis (Kulczyński, 1887) syn. nov.; Zilla diodia embrikstrandi Kolosváry, 1938 = Zilla diodia (Walckenaer, 1802) syn. nov.; Zygiella x-notata chelata (Franganillo, 1909) and Zygiella x-notata parcechelata (Franganillo, 1909) = Zygiella x-notata (Clerck, 1757) syn. nov.; Teutana grossa obliterata Franganillo, 1913 = Steatoda grossa (C. L. Koch, 1838) syn. nov.
14 citations
TL;DR: The Manchester Synthetic Biology Research Centre's integrated technology platforms provide a unique capability to facilitate predictable engineering of microbial bio-factories for chemicals production.
Abstract: The Manchester Synthetic Biology Research Centre (SYNBIOCHEM) is a foundry for the biosynthesis and sustainable production of fine and speciality chemicals. The Centre's integrated technology platforms provide a unique capability to facilitate predictable engineering of microbial bio-factories for chemicals production. An overview of these capabilities is described.
7 citations
TL;DR: An overview of foundry activities that are being applied to grand challenge projects to deliver innovation in bio-based chemicals production for industrial biotechnology is provided.
7 citations
30 Sep 2016
TL;DR: This work reports that both of these species have very close relationships to similarly uncommon species originally described from France at about the same time, expanding the range of this species considerably to the East and confirming that it is a genuine European species, rather than a recent immigrant from North America as previously suspected.
Abstract: Cheiracanthium rupestre Herman, 1879, and Xysticus albomaculatus Kulczyński, 1891, both originally described from Hungary, are among the most rarely reported species of their genera in Europe. Here we report that both of these species have very close relationships to similarly uncommon species originally described from France at about the same time. The specimens currently considered as Cheiracanthium rupestre turn out to be very closely related to, but distinct from, Cheiracanthium striolatum Simon, 1878. However, the original description of C. rupestre does not match these specimens nor any other known species of Cheiracanthium. We therefore consider C. rupestre a nomen dubium and suggest that all previous records of this species after the original description actually refer to Cheiracanthium macedonicum Drensky, 1921. Xysticus albomaculatus, on the other hand, turns out to be a junior synonym of Bassaniana baudueri (Simon, 1877) syn. nov., expanding the range of this species considerably to the East and at the same time confirming that it is a genuine European species, rather than a recent immigrant from North America as previously suspected.
4 citations