Maria Vinaixa

TL;DR: The main characteristics of the mass spectral databases currently used in MS-based metabolomics are reviewed in this paper, underlining their advantages and limitations, and the overlap of compounds with MSn (n ≥ 2) spectra from authentic chemical standards in most public and commercial databases has been calculated for the first time.

TL;DR: This paper reports on a comprehensive overview of a workflow for statistical analysis to rank relevant metabolite features that will be selected for further MS/MS experiments, focusing on univariate data analysis applied in parallel on all detected features.

TL;DR: An automated pipeline for the discovery and optimization of biosynthetic pathways for microbial production of fine chemicals is presented and application of the pipeline to optimize an alkaloids pathway demonstrates how it could facilitate the rapid optimization of microbial strains for production of any chemical compound of interest.

TL;DR: Dietary cholesterol is a causal factor in the development of both liver steatosis and hepatic inflammation, and (1)H NMR metabolomics is used for quantitative profiling of liver extracts from LDLr(-/-) mice.

TL;DR: The Liposcale test, a novel ALT based on 2D diffusion-ordered 1H NMR spectroscopy, provides reproducible and reliable characterization of lipoprotein particles and it is applicable to pathological states such as AD.