N
Nicholas J. W. Rattray
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 79
Citations - 2203
Nicholas J. W. Rattray is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 22, co-authored 69 publications receiving 1627 citations. Previous affiliations of Nicholas J. W. Rattray include Yale University & Max Planck Society.
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Journal ArticleDOI
New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition
Karl A. P. Payne,Mark D. White,Karl Fisher,Basile Khara,Samuel S. Bailey,David A. Parker,Nicholas J. W. Rattray,Drupad K. Trivedi,Royston Goodacre,Rebecca Beveridge,Perdita E. Barran,Stephen E. J. Rigby,Nigel S. Scrutton,Sam Hay,David Leys +14 more
TL;DR: It is shown that Fdc1 is solely responsible for the reversible decarboxylase activity, and that it requires a new type of cofactor: a prenylated flavin synthesized by the associated UbiX/Pad1, which offers new routes in alkene hydrocarbon production or aryl (de)carboxylation.
Journal ArticleDOI
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
Mark D. White,Karl A. P. Payne,Karl Fisher,Stephen A. Marshall,David A. Parker,Nicholas J. W. Rattray,Drupad K. Trivedi,Royston Goodacre,Stephen E. J. Rigby,Nigel S. Scrutton,Sam Hay,David Leys +11 more
TL;DR: The mechanism for formation of a new flavin-derived cofactor required for the decarboxylase activity of UbiD is established, extending both flavin and terpenoid biochemical repertoires.
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An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
Pablo Carbonell,Adrian J. Jervis,Christopher J. Robinson,Cunyu Yan,Mark S. Dunstan,Neil Swainston,Maria Vinaixa,Katherine A. Hollywood,Andrew Currin,Nicholas J. W. Rattray,Sandra Taylor,Reynard Spiess,Rehana Sung,Alan Williams,Donal Fellows,Natalie J. Stanford,Paul Mulherin,Rosalind Le Feuvre,Perdita E. Barran,Royston Goodacre,Nicholas J. Turner,Carole Goble,George Guo-Qiang Chen,George Guo-Qiang Chen,Douglas B. Kell,Jason Micklefield,Rainer Breitling,Eriko Takano,Jean-Loup Faulon,Jean-Loup Faulon,Nigel S. Scrutton +30 more
TL;DR: An automated pipeline for the discovery and optimization of biosynthetic pathways for microbial production of fine chemicals is presented and application of the pipeline to optimize an alkaloids pathway demonstrates how it could facilitate the rapid optimization of microbial strains for production of any chemical compound of interest.
Journal ArticleDOI
Systems biology guided by XCMS Online metabolomics
Tao Huan,Erica M. Forsberg,Duane Rinehart,Caroline H. Johnson,Caroline H. Johnson,Julijana Ivanisevic,H. Paul Benton,Mingliang Fang,Mingliang Fang,Aries E. Aisporna,Brian Hilmers,Farris L. Poole,Michael P. Thorgersen,Michael W. W. Adams,Gregory P. Krantz,Matthew W. Fields,Paul D. Robbins,Laura J. Niedernhofer,Trey Ideker,Erica L.-W. Majumder,Judy D. Wall,Nicholas J. W. Rattray,Nicholas J. W. Rattray,Royston Goodacre,Luke L. Lairson,Gary Siuzdak +25 more
TL;DR: An 'integrated-omics' approach within XCMS Online1 that automatically superimposes raw metabolomic data onto metabolic pathways and integrates it with transcriptomic and proteomic data is reported.
Journal ArticleDOI
Taking your breath away: metabolomics breathes life in to personalized medicine
Nicholas J. W. Rattray,Zahra Hamrang,Drupad K. Trivedi,Royston Goodacre,Stephen J. Fowler,Stephen J. Fowler +5 more
TL;DR: Recent improvements and directions in the development of breath VOC analysis and diagnosis platforms that offer the potential for disease biomarker discovery and disease prognosis are discussed.