R
Rajatava Basu
Researcher at University of Alabama at Birmingham
Publications - 24
Citations - 1470
Rajatava Basu is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Leishmania donovani & T cell. The author has an hindex of 12, co-authored 23 publications receiving 1254 citations. Previous affiliations of Rajatava Basu include Indian Institute of Chemical Biology & Charité.
Papers
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Journal ArticleDOI
Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Rajatava Basu,Darrell B. O'Quinn,Daniel J. Silberger,Trenton R. Schoeb,Lynette A. Fouser,Wenjun Ouyang,Robin D. Hatton,Casey T. Weaver +7 more
TL;DR: It is found that the enteric pathogen Citrobacter rodentium induced sequential waves of IL-22-producing ILCs and CD4(+) T cells that were each critical to host defense during a primary infection.
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Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis.
TL;DR: This is the first report of a vaccine conferring protection to both antimony responsive and resistant Leishmania strains reflecting several aspects of clinical visceral leishmaniasis.
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The Th17 family: flexibility follows function.
TL;DR: The developmental and functional features of Th17 cells in relation to iTreg cells, Th1 cells, and Th22 cells are examined, as a basis for understanding the contributions of this pathway to host defense, immune homeostasis, and immune‐mediated disease.
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IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance
Rajatava Basu,Sarah K. Whitley,Suniti Bhaumik,Carlene L. Zindl,Trenton R. Schoeb,Etty N. Benveniste,Warren S. Pear,Robin D. Hatton,Casey T. Weaver +8 more
TL;DR: It is found that IL-1 was needed to fully override RA-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses and modulated STAT activation downstream of cytokine receptors differently to control the TH 17 cell–iTreg cell developmental fate.
Journal ArticleDOI
Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response.
Suniti Bhaumik,Rajatava Basu +1 more
TL;DR: The expanding sphere of Th17 plasticity is discussed through its shared developmental axes with related cellular subsets such as Th22, Th1, and iTreg in the context of intestinal inflammation and also examines the molecular and epigenetic features of Th 17 cells that mediate these overlapping developmental programs.