R
Rajeev Ranjan
Researcher at University of Cologne
Publications - 4
Citations - 1021
Rajeev Ranjan is an academic researcher from University of Cologne. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 4, co-authored 4 publications receiving 853 citations.
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Journal ArticleDOI
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Tina Lucas,Ari Waisman,Rajeev Ranjan,Jürgen Roes,Thomas Krieg,Werner Müller,Axel Roers,Sabine A. Eming +7 more
TL;DR: The results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events.
Journal ArticleDOI
CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds.
Kosmas Kosmas,Ali Eskandarnaz,Arya B. Khorsandi,Atul Kumar,Rajeev Ranjan,Sabine A. Eming,Angelika A. Noegel,Vivek S. Peche +7 more
TL;DR: A role for CAP2 in wound healing is revealed which may be based on its function as a regulator of the actin cytoskeleton and Interestingly, CAP1 was upregulated in knockout unwounded skin and in wounds which might partially compensate for the loss of CAP2.
Journal ArticleDOI
Leptin signaling impairs macrophage defenses against Salmonella Typhimurium.
Julia Fischer,Saray Gutiérrez,Raja Ganesan,Chiara Calabrese,Rajeev Ranjan,Gökhan Cildir,Nina Judith Hos,Jan Rybniker,Martina Wolke,Jochen W.U. Fries,Vinay Tergaonkar,Georg Plum,Adam Antebi,Adam Antebi,Nirmal Robinson,Nirmal Robinson +15 more
TL;DR: It is shown that leptin induction activates the mTORC2/Akt pathway and subsequently down-regulates Phlpp1 phosphatase, allowing for phosphorylated Akt to impair lysosomal-mediated pathogen clearance, and have important therapeutic implications for modulating innate immunity to combat Gram-negative bacterial infections.
Chronic Wounds and Inflammation
TL;DR: A more detailed understanding in mechanisms controlling the inflammatory response during repair and how inflammation directs the outcome of the healing process will serve as a significant milestone in the therapy of pathological tissue repair.